23:38 , Oct 18, 2017 |  BC Innovations  |  Translation in Brief

Neutrophil bias

Researchers from the University of Texas Health Science Center have found that IL-27 promotes an anti-inflammatory phenotype in neutrophils that can treat stroke in mice. But safety issues around the recombinant cytokine have the team...
07:00 , Oct 3, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Viral infection IL-6 signal transducer (IL-6ST; gp130; CD130); IL-27; IL-27 receptor-a (IL27RA) Mouse studies suggest increasing IL-27 signaling through gp130 and IL27RA could help...
08:00 , Jan 27, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Gastrointestinal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Gastrointestinal disease Colitis IL-27 receptor a (IL27RA) A study in mice suggests that antagonizing IL27RA could help treat colitis. In a mouse model of colitis, transfer...