00:53 , Jan 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Epilepsy Cell culture and rat studies identified a benzodiazepine-based triple-inhibitor of CACNA1G , CACNA1H and CACNA1I that could help treat epilepsy. Chemical synthesis and testing in HEK cells expressing the three calcium channels identified...
07:00 , Jun 11, 2012 |  BioCentury  |  Emerging Company Profile

Xdynia: T type relief

Xdynia LLC spun out from Tau Therapeutics Inc . this year to develop oral small molecule inhibitors of a specific subset of voltage-dependent T type calcium channels that play a prominent role in pain signal...
07:00 , Jun 11, 2009 |  BC Innovations  |  Cover Story

Eat, sleep, lose weight

Researchers at Merck & Co. Inc. may have found a way to tackle obesity by antagonizing T-type calcium channels, which are involved in sleep regulation. In rodents, the approach reduced diet-induced weight gain and increased...
07:00 , Jun 11, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Obesity Calcium channel voltage-dependent T-type a1G subunit (CACNA1G; Cav3.1) Studies in rodents suggest that antagonizing the T-type calcium channel CACNA1G...
07:00 , May 21, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Vesicular monoamine transporter 2 (SLC18A2; VMAT2); dopa decarboxylase (DDC; AADC); calcium channel voltage-dependent T type-α 1G subunit (CACNA1G;...
08:00 , Feb 19, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Neurology Epilepsy Calcium channel voltage-dependent T-type a1G subunit (CACNA1G; Cav3.1) Mouse studies suggest that targeting T-type calcium channels could help treat...