07:00 , Oct 15, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Sterol O-acyltransferase 2 (SOAT2; ACAT2)

Cardiovascular disease INDICATION: Atherosclerosis; hypercholesterolemia In vitro and mouse studies identified an SOAT2 inhibitor that could help treat atherosclerosis and hypercholesterolemia. Chemical synthesis and in vitro testing of pyripyropene A analogs yielded a compound that...
08:00 , Feb 25, 2010 |  BC Innovations  |  Cover Story

Cholesterol metabolism ADds up

Reports by independent teams at Dartmouth College and Albert Einstein College of Medicine of Yeshiva University suggest that blocking production and transport of cholesteryl esters, the extracellular form of cholesterol, could be useful for treating...