13:10 , Dec 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Inflammation

INDICATION: Inflammation In vitro , cell culture and mouse studies identified an OGG1 inhibitor that could help treat pulmonary inflammation. Screening of a small molecule library via an in vitro activity assay, followed by optimization...
13:23 , Nov 16, 2018 |  BC Extra  |  Preclinical News

Preventing DNA repair blocks inflammation

In Science , researchers at Karolinska Institute and colleagues reported a new approach to treat inflammatory diseases by blocking repair of inflammation-induced oxidative DNA damage. Reactive oxygen species (ROS) generated by inflammation induce oxidative DNA...
02:11 , Dec 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Pathways emerging from ASH

A survey of the emerging molecular targets at this year’s American Society of Hematology conference indicates that while harnessing the immune system to treat cancer remains a dominant interest, processes for tuning protein levels --...
07:00 , Apr 11, 2011 |  BC Week In Review  |  Clinical News

Tarceva erlotinib: Additional Phase II data

Researchers at the M.D. Anderson Cancer Center reported additional data from a subgroup of 101 stage IV NSCLC patients who had gene expression profiles obtained from pretreatment core needle biopsies in the adaptive, open-label, U.S....