BioCentury | Sep 9, 2020
Product Development

Intra-Cellular eyes broad label for bipolar depression after Phase III hit

...to start a trial of the dual serotonin (5-HT2A) receptor...
...HT2RA) – Serotonin receptor 2A Lauren Martz Caplyta, lumateperone (ITI-007) Intra-Cellular Therapies Inc. Serotonin receptor 2A (5-HT2A) (HT2RA) Neurology Bipolar...
BioCentury | May 29, 2020
Product Development

Minerva’s schizophrenia miss casts doubt on approach to treating negative symptoms

...candidate is pimavanserin, which it markets as Nuplazid for Parkinson’s disease psychosis. The small molecule 5-HT2A...
...Acadia intends to begin a second pivotal study, the ADVANCE-2 trial. Targets 5-HT2A (HT2RA) - Serotonin receptor 2A...
...HCRTR2) - Orexin 2 receptor TMEM97 - Sigma-2 receptor Paul Bonanos, Associate Editor Roluperidone, MIN-101, cyr-101, mt-210, CYR101 Serotonin receptor 2A (5-HT2A) (HT2RA) Sigma-2...
BioCentury | Jan 11, 2020
Finance

Why buysiders say 2020 could be the year of the CNS

...the Phase II ADVANCE trial of pimavanserin for schizophrenia in November. Acadia already markets the 5-HT2A...
BioCentury | Dec 23, 2019
Company News

Caplyta’s unanticipated schizophrenia approval lifts Intra-Cellular shares

...added more than $1.3 billion to the company’s market cap. The agency approved the dual serotonin (5-HT2A) receptor...
...drug’s price closer to launch. Targets: 5-HT2A (HT2RA) - Serotonin receptor 2A Lauren Martz, Associate Editor lumateperone (ITI-007) Intra-Cellular Therapies Inc. Serotonin receptor 2A (5-HT2A) (HT2RA)...
BioCentury | Dec 5, 2019
Clinical News

Dementia-related psychosis data could make Acadia’s pimavanserin a blockbuster

...p=0.0024). The drug is a serotonin inverse agonist and antagonist that preferentially targets serotonin receptor 2A (5-HT2A; HT2RA...
BioCentury | Nov 15, 2019
Product Development

Minerva on the verge in neuropsychiatry with two compounds close to verdict

...marketed antipsychotics, roluperidone works via polypharmacology, affecting multiple neurotransmitter systems. Its primary actions are at 5-HT2A...
...and improvement of negative symptoms,” said Luthringer. He thinks 5-HT2A antagonism could accomplish the former. 5-HT2A...
...a mouse model of the disease. Targets 5-HT1A - Serotonin 5-HT1A receptor 5-HT2A - Serotonin 5-HT2A...
BioCentury | Oct 17, 2019
Preclinical News

Oct. 17 Preclinical Quick Takes: Miromatrix, Mayo extend vascular function in liver graft scaffold; plus James Allison-MD Anderson, Northwestern and Eleusis

...in Life Sciences that agonizing serotonin receptors could reduce lung inflammation in chronic asthma. A 5-HT2A...
...the disease. The company is developing 5-HT2A agonists for chronic inflammation. Targets: 5-HT2A (HT2RA) - Serotonin receptor 2A...
...membrane protein 2B BioCentury Staff Northwestern University Lysosomal Therapeutics Inc. Mayo Clinic University of Texas MD Anderson Cancer Center Miromatrix Medical Inc. Serotonin receptor 2A (5-HT2A) (HT2RA) G...
BioCentury | Sep 9, 2019
Clinical News

Dementia-related psychosis readout could lead to label expansion for Acadia's Nuplazid

...in 1H19 from $105.9 million in 1H18. The drug is a small molecule serotonin receptor 2A (5-HT2A; HT2RA...
BioCentury | Jul 24, 2019
Company News

July 23 Company Quick Takes: FDA approves Pfizer’s Rituxan biosimilar; plus Intra-Cellular, OTC Tamiflu, Cimzia and more

...NDA for lumateperone to treat schizophrenia, citing “new information regarding the application.” Lumateperone is a 5-HT2A...
...290kDa; USH2A - Usher syndrome 2A; TNFα - Tumor necrosis factor α; 5-HT2A (HT2RA) - serotonin receptor 2A BioCentury...
BioCentury | Jul 23, 2019
Clinical News

Acadia looks to next schizophrenia readout after Phase III miss

...the ADVANCE's results before deciding on next steps. The small molecule inverse agonist of the 5-HT2A...
...and delusions associated with Parkinson’s disease psychosis. Sandi Wong, Staff Writer Nuplazid, pimavanserin (ACP-103, pimavanserin tartrate) Acadia Pharmaceuticals Inc. Serotonin receptor 2A (5-HT2A) (HT2RA) Schizophrenia...
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