BioCentury | Apr 4, 2017
Clinical News

Researchers suggest ipgm-1 inhibitor could treat infections

...led by NIH and University of Tokyo researchers identified cyclic peptide inhibitors of the enzyme 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)... James Inglese of NIH’s NCATS told BioCentury small molecules have shown weak inhibition of ipgm-1...
...selectivity over the human isozyme. Two compounds showed sub-nanomolar inhibition of ipgm-1. Structural analysis of ipgm-1...
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