BioCentury | Dec 21, 2018
Clinical News

Medix planning Mexican NDA for obesity candidate

...tesofensine/metoprolol, a fixed-dose combination of tesofensine and the selective adrenergic receptor β 1 (ADRB1) blocker metoprolol...
BioCentury | Mar 2, 2018
Clinical News

Arca reports Phase IIb data for Gencaro in heart failure patients

...bucindolol hydrochloride led to a "similar treatment benefit" on the primary endpoint compared to Toprol-XL metoprolol...
BioCentury | Jan 26, 2018
Clinical News

Saniona reports data from exploratory Phase IIa of Tesomet for Prader-Willi

...Saniona AB (SSE:SANION) said data from an exploratory Phase IIa trial evaluating once-daily Tesomet tesofensine/metoprolol in...
...the endpoint. Tesomet is a fixed-dose combination of tesofensine, a triple monoamine reuptake inhibitor, and metoprolol...
...a selective adrenergic receptor beta 1 (ADRB1) blocker. Saniona AB (SSE:SANION), Ballerup, Denmark Product: Tesomet tesofensine/metoprolol...
BioCentury | Jun 9, 2017
Company News

AstraZeneca grants Recordati commercial rights to Seloken

...S.p.A. (Milan:REC) European commercial rights to Seloken metoprolol tartrate, Seloken ZOK metoprolol succinate and Logimax metoprolol...
...front. AstraZeneca will manufacture and supply the products and is eligible to receive double-digit royalties. Seloken...
...blocker marketed to treat hypertension, angina and heart failure. Logimax, a fixed-dose combination of metoprolol...
BioCentury | May 17, 2017
Clinical News

Saniona begins Phase IIa of Tesomet for Prader-Willi syndrome

...double-blind, placebo-controlled, Czech and Hungarian Phase IIa TM002 trial to evaluate 0.5 mg/50 mg Tesomet tesofensine/metoprolol...
...in 2018. Tesomet is a fixed-dose combination of tesofensine, a triple monoamine reuptake inhibitor, and metoprolol...
...a selective adrenergic receptor beta 1 (ADRB1) blocker. Saniona AB (SSE:SANION), Ballerup, Denmark Product: Tesomet tesofensine/metoprolol...
BioCentury | Jan 27, 2017
Clinical News

Tesomet: Ph IIa data

...Phase IIa trial in 60 Type II diabetics showed that 0.5 mg/100 mg oral Tesomet tesofensine/metoprolol...
...restlessness reported as the most common adverse events. Saniona AB (SSE:SANION), Ballerup, Denmark Product: Tesomet tesofensine/metoprolol...
...1 ( ADRB1 ) Description: Fixed-dose combination of tesofensine, a triple monoamine reuptake inhibitor, and metoprolol...
BioCentury | Oct 10, 2016
Company News

AstraZeneca, Aralez deal

...Aralez Pharmaceuticals Trading DAC subsidiary exclusive, U.S. rights to market branded and authorized generic Toprol-XL metoprolol...
BioCentury | Apr 16, 2015
Distillery Techniques

Techniques: Rat-based model of oral bioavailability as a function of gastrointestinal (GI) fluid volumes

...absorption of atenolol - a drug with low intestinal permeability - more than absorption of metoprolol...
BioCentury | Apr 21, 2014
Clinical News

Gencaro bucindolol: Phase IIb/III started

...100 mg oral Gencaro twice daily vs. 25, 50, 100 and 200 mg oral Toprol-XL metoprolol...
...a company jointly owned by Aeolus and Endo. AstraZeneca plc (LSE:AZN; NYSE:AZN, London, U.K.) markets Toprol-XL...
BioCentury | Dec 16, 2013
Clinical News

Gencaro bucindolol: Phase IIb/III start

...100 mg oral Gencaro twice daily vs. 25, 50, 100 and 200 mg oral Toprol-XL metoprolol...
...a company jointly owned by Aeolus and Endo. AstraZeneca plc (LSE:AZN; NYSE:AZN, London, U.K.) markets Toprol-XL...
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