BioCentury | Oct 31, 2018
Distillery Therapeutics

Hepatic; renal

...liver disease (NAFLD) and acute kidney injury (AKI). In mouse primary hepatocytes, the ACMSD inhibitor TES-991...
...the ACMSD inhibitor TES-1025 decreased apoptosis. In a mouse model of diet-induced NAFLD, pretreatment with TES-991...
...include clinical testing of TES-1025 and TES-991 in NAFLD and AKI patients. TES Pharma has TES-991...
BioCentury | Oct 25, 2018
Preclinical News

Inhibiting metabolic enzyme to prevent NAFLD, acute kidney injury

...Medicinal Chemistry study , the team aimed to target the NAD+ synthesis pathway by developing TES-991...
...mouse kidneys and livers. In a Nature paper published Wednesday, the group showed that prophylactic TES-991...
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