...cancer The antimalarial drug lumefantrine, an FLI1 inhibitor, could treat glioblastoma resistant to radiation and temozolomide...
...and 77.1 μM. Lumefantrine also blocked the cells’ migration and infiltration. In cultured radiation- and temozolomide-resistant...
...50 values of 73.1-185.3 μM. In xenograft mouse models of glioblastoma resistant to radiation or temozolomide...

...Zai, Novocure secure Optune approval in China NMPA also approved an MAA for Optune plus temozolomide...

...indication fail over the course of her neurosurgery residency. The standard of care for GBM, temozolomide...
...nature of recurrent GBM, Singh developed a patient-derived xenograft mouse model that is treated with temozolomide...

...the company’s RTT policy, patients must have GBM that has not responded to treatment with temozolomide...

...548 trial to treat glioblastoma multiforme, missing one of its primary endpoints. The trial evaluated temozolomide...

...of Clinical Oncology meeting had shown that Depatux-M plus temozolomide improved OS by 32% vs. temozolomide...
...O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated GBM. INTELLANCE-1 evaluated Depatux-M vs. placebo when given with concurrent radiation and temozolomide...

...PD-1 inhibitor Opdivo nivolumab plus radiation missed the primary endpoint of improving overall survival vs. temozolomide...
...O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated glioblastoma multiforme. The Phase III CheckMate -548 trial is evaluating Opdivo plus temozolomide...

...same lines, STAG2 knockout increased sensitivity to the chemotherapies and dsDNA break repair inhibitors gemcitabine, temozolomide...

...the combination plus temozolomide had an 83% one-year survival rate vs. 53% for placebo plus temozolomide...

...identified a naphthoquinone-based compound that inhibited cell viability with greater potency than the generic chemotherapy temozolomide...