...mtDNA) released from prostate cancer cells could treat prostate cancer and enhance the efficacy of docetaxel... ...antagonist tool compound or fibroblast-specific TLR9 knockout reduced tumor growth. The C3AR1 antagonist also resensitized docetaxel-resistant... ...cancer cells co-cultured with CAFs, and reduced tumor growth in a xenograft mouse model of docetaxel-resistant...
...Inc. (NYSE:PFE) / Clovis Oncology Inc. (NASDAQ:CLVS) Rubraca rucaparib Ph III Monotherapy Zytiga, Xtandi or docetaxel... ...testing Merck & Co.’s Keytruda pembrolizumab in combination with Xtandi, PARP inhibitor Lynparza olaparib, or docetaxel... ...were underwhelming. ORRs were 20% in combination with Xtandi, 7% with Lynparza and 14% with docetaxel...