BioCentury | Apr 1, 2020
Distillery Therapeutics

FLNA identified as a target for epilepsy associated with focal cortical dysplasia type II

...II, an shRNA against FLNA lowered seizure frequency by 83% and prevented disease-associated neuronal misplacement, soma...
...model, the small molecule FLNA inhibitor PTI-125 given before or after seizure onset lowered neuronal soma...
BioCentury | Mar 13, 2020
Management Tracks

Camerini steps down as Cosmo CSO; plus CytoDyn, G1 Therapeutics, Flexion and Clearside

...CCR5 antagonist leronlimab in a COVID-19 clinical trial. Cancer company G1 Therapeutics Inc. (NASDAQ:GTHX) hired Soma...
BioCentury | Mar 11, 2020
Product Development

Novo’s year of obesity

...year by Langer’s lab and Novo scientists showed that an ingestible self-orientating millimeter scale applicator (SOMA...
BioCentury | Mar 8, 2019
Targets & Mechanisms

Oral insulin innovation

...Massachusetts Institute of Technology (Robert Langer) / Novo Nordisk A/S (CSE:NOVOB; NYSE:NVO) Self-Orienting Millimeter-scale Actuator (SOMA...
...8 Science paper . The study describes a GI injection device dubbed Self-Orienting Millimeter-scale Applicator (SOMA...
...using Entrega’s delivery vehicle. Rani is developing an oral gastrointestinal injection device similar to the SOMA...
BioCentury | Feb 13, 2019
Distillery Techniques

Drug delivery

...of biologics for injection into the stomach lining. The device is a self-orienting millimeter-scale applicator (SOMA...
...SOMA-delivered insulin was comparable to that of subcutaneously or intragastrically injected insulin. Also in pigs, SOMA-delivered...
...the two other routes of injection. Next steps by Novo Nordisk A/S include test the SOMA...
BioCentury | Feb 7, 2019
Preclinical News

Novo, MIT develop oral biologic delivery device

...including insulin, directly to the gastric mucosa. The device -- called a self-orienting millimeter-scale applicator (SOMA...
...of the GI tract. Lars Iversen, Novo's SVP of global research technologies, told BioCentury, "The SOMA...
...is not limited by a drug's molecular weight. Described in a Science paper , the SOMA...
BioCentury | Sep 29, 2016
Distillery Therapeutics

Therapeutics: TCP1 containing ring complex (TRiC); T-complex 1 (TCP1; CCT1); chaperonin containing TCP1 subunit 3 (CCT3), CCT5; CCT7; CCT8; huntingtin (HTT)

...apical domain of TCP1 decreased striatal neuron atrophy and increased synaptic connectivity and striatal neuron soma...
BioCentury | Sep 19, 2013
Distillery Therapeutics

Indication: Neurology

...of Mecp2 yielded physiologically relevant levels of Mecp2 in the brain and restored normal neuronal soma...
BioCentury | Feb 8, 2010
Clinical News

Soma carisoprodol: Pivotal trial data

...data from a pair of double-blind pivotal trials in >1,300 patients showed that 250 mg Soma...
...global impression of change and relief from starting backache vs. placebo at day 3 (p<0.0001). Soma...
...associated with acute, painful musculoskeletal conditions in adults. Meda AB (SSE:MEDAA), Solna, Sweden Product: Soma carisoprodol...
BioCentury | Oct 16, 2000
Company News

Advanced Cell Technology other research news

...give birth to a gaur bull, an ox-like animal. The company is collaborating with the Soma...
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