BioCentury | Mar 28, 2020
Translation in Brief

17 FDA-approved drugs show activity against SARS-CoV-2; two groups seek COVID-19 patient-derived mAbs; plus NYU, Scholar Rock and LIfT-King's College

...and Middle-East respiratory syndrome (MERS) coronaviruses. The 17 drugs -- including chloroquine, hydroxychloroquine, cancer therapy tamoxifen...
BioCentury | Nov 19, 2019

AGR2 and LYPD3 as breast cancer targets

...growth of two human tamoxifen-resistant breast cancer cell lines. In a xenograft mouse model of tamoxifen-resistant...
BioCentury | May 31, 2019
Targets & Mechanisms

Targeting cancer evolution offers a way to foil drug resistance

...poor response to tamoxifen in breast cancer patients, and inhibiting the enzyme increased sensitivity to tamoxifen...
BioCentury | Oct 25, 2018
Distillery Therapeutics

Cancer

...non-specific siRNA, and in the tamoxifen-resistant breast cancer cell line, the two ANKLE2-targeting siRNAs plus tamoxifen...
...breast cancer cell line, the two ANKLE2-targeting siRNAs plus tamoxifen increased cell death compared with tamoxifen...
...of tamoxifen-resistant breast cancer, tumor-specific knockdown of ANKLE2 plus tamoxifen decreased tumor size compared with tamoxifen...
BioCentury | Sep 19, 2018
Distillery Techniques

Assays and screens; biomarkers; other

...p≤0.05). In 24 ovarian cancer and 49 stomach adenocarcinoma patients, the model predicted resistance to tamoxifen...
BioCentury | Aug 17, 2018
Targets & Mechanisms

Unsaturated remyelination

...for eight days with either the TM7SF2 inhibitor ifenprodil (n=6; p=0.0004) or the EBP inhibitor tamoxifen...
...measurements confirmed the treated animals had higher levels of sterols in their brains (ifenprodil, p=0.0003; tamoxifen...
...remyelination, supporting the claim that remyelination depends more on 8,9-unsaturated sterol production than muscarinic inhibition. Tamoxifen...
BioCentury | Jun 28, 2018
Distillery Therapeutics

Cancer

...oral administration of the compound decreased tumor growth compared with subcutaneous Faslodex fulvestrant or oral tamoxifen...
...Faslodex, a selective estrogen receptor down-regulator (SERD), for breast cancer. The generic estrogen receptor antagonist tamoxifen...
BioCentury | May 18, 2018
Company News

Dare acquiring Pear Tree

...will acquire Pear Tree Pharmaceuticals Inc. (Cambridge, Mass.), gaining its PT-101. The vaginal formulation of tamoxifen...
BioCentury | May 9, 2018
Distillery Therapeutics

Cancer

...sample and cell culture studies suggest inhibiting BARD1, BRCA1, CDK1 or CKD12 could help treat tamoxifen-resistant...
...cancer. In tumor tissue from 27 recurrent breast cancer patients whose tumors became resistant to tamoxifen...
...and BRCA1 expression was higher in relapsed tumors than in matched primary tumors. In two tamoxifen-resistant...
BioCentury | Apr 18, 2018
Distillery Therapeutics

Cancer

...normal expression. In the genetic model, knockout of PDGFCC plus the generic estrogen receptor antagonist tamoxifen...
...PDGFCC knockout alone. In two orthotopic mouse models of breast cancer, an anti-PDGFCC mAb plus tamoxifen...
...published online March 12, 2018 doi:10.1038/nm.4494 CONTACT: Kristian Pietras, Lund University, Lund, Sweden email: kristian.pietras@med.lu.se Chris Lieu tamoxifen Lund...
Items per page:
1 - 10 of 268