BC Extra | Sep 5, 2019
Preclinical News

2016 study on gut integrin HIV target can't be replicated

Three preclinical studies and one clinical trial could not replicate the antiviral effects of an antibody against α4β7 to treat HIV or simian immunodeficiency virus, casting doubt on a theory that preventing CD4+ T cells...
BC Extra | May 20, 2019
Clinical News

May 20 Clinical Quick Takes: Keytruda misses in TNBC; plus Medicines Co., Acadia, Takeda, Ocular

Keytruda fails in previously treated TNBC  Monotherapy with PD-1 inhibitor Keytruda pembrolizumab from Merck & Co. Inc. (NYSE:MRK) missed the primary endpoint of improving overall survival vs. physician’s choice of single agent chemotherapy in the...
BioCentury | Jan 5, 2019
Finance

Ready to launch

  The proposed $74 billion takeout of Celgene Corp. by Bristol-Myers Squibb Co. will not shift buysider attention away from upcoming and maturing drug launches heading into 2019, with plenty to track following a record...
BC Week In Review | Nov 2, 2018
Company News

Takeda proposes divestment of Shire GI candidate, announces loans

Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) said it proposed to the European Commission a potential divestment of Crohn’s disease and ulcerative colitis candidate SHP647 once it completes its acquisition of Shire plc (LSE:SHP; NASDAQ:SHPG). The move...
BC Week In Review | Sep 7, 2018
Clinical News

Abivax's ABX464 improves mucosal healing, Mayo Score in Phase IIa for UC

Abivax S.A. (Euronext:ABVX) said ABX464 improved mucosal healing rate (50% vs. 11%, p=0.03) and reduced partial (62% vs. 32%, p<0.02) and total Mayo Scores (53% vs. 37%, p<0.03) at eight weeks vs. placebo in 29...
BC Week In Review | Aug 3, 2018
Clinical News

Takeda's subcutaneous Entyvio meets in Phase III for maintenance therapy of ulcerative colitis

Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) said subcutaneous Entyvio vedolizumab as maintenance therapy met the primary endpoint vs. placebo in the Phase III VISIBLE 1 trial to treat ulcerative colitis in patients who achieved a clinical...
BioCentury | Jul 13, 2018
Strategy

Roche’s partnering priority

As James Sabry gets set to lead partnering for all of Roche pharma, his first order of business might be to build out the company’s late-stage pipeline ahead of an impending patent cliff that puts...
BC Week In Review | Dec 1, 2017
Company News

Takeda, Portal partner to develop needle-free biologics

Portal Instruments Inc. (Cambridge, Mass.) partnered with Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) to develop and commercialize Portal’s needle-free drug delivery device for use with Takeda’s investigational and approved biologics. The device delivers biologics through a...
BioCentury | Jun 24, 2017
Strategy

Takeda’s modality operandi

Takeda Pharmaceutical Co. Ltd. is moving beyond its traditional small molecule approach into new modalities with the goal of delivering therapeutics that provide a step change for patients. To get there, Takeda is using a...
BC Innovations | May 31, 2017
Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers A gut microbiome-based model could help predict responses to Entyvio vedolizumab in Crohn's disease and UC patients. Metagenomic analysis of fecal samples from 42 Crohn's disease patients receiving Entyvio identified associations between...
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