BioCentury | Mar 10, 2020
Product Development

March 9 Quick Takes: A first for Boehringer’s Ofev; plus Cel-Sci’s COVID-19 therapy, Sinopharm, AZ, Urovant, Hengrui, Trevena, and Tetra-Shionogi

...hepatocellular carcinoma (HCC) patients previously treated with the tyrosine kinase inhibitor Nexavar sorafenib or systemic oxaliplatin...
BioCentury | May 10, 2019
Targets & Mechanisms

The tumor microbiome emerges as a new source of translational opportunities

...a 2017 paper . But a 2013 paper showed some bacteria increase the efficacy of oxaliplatin... reversed with antibiotic treatment. However, other researchers have shown antibiotics weakened the effects of oxaliplatin...
BioCentury | Apr 30, 2019
Distillery Therapeutics

Oxaliplatin- and dihydroartemesinin-loaded nanoparticles for colorectal cancer

...oxaliplatin and dihydroartemesinin could help treat colorectal cancer. The nanoparticles consist of a core of oxaliplatin...
BioCentury | Oct 26, 2018
Clinical News

Alphamab Oncology, 3DMed start Phase III for PD-L1 antibody in cholangiocarcinoma

...3D Medicines Corp. (Shanghai, China) began a Phase III trial of KN035 plus gemcitabine and oxaliplatin...
BioCentury | Sep 21, 2018
Tools & Techniques

Precision for pancreatic cancer

...eight patients who had HRD signatures but no BRCA1 or BRCA2 mutations were treated with oxaliplatin-based...
...the pharmacotyping. Transcriptomic profiling revealed gene signatures that correlated with response to either gemcitabine or oxaliplatin...
BioCentury | Jul 13, 2018
Clinical News

Opdivo plus Yervoy approved for mCRC

...mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC) that has progressed following treatment with fluoropyrimidine, oxaliplatin...
BioCentury | Apr 13, 2018
Emerging Company Profile

Reversing Neuropathy

...ethyldiamine (PLED) analog, in Phase III to prevent CIPN in metastatic colorectal cancer patients receiving oxaliplatin...
BioCentury | Mar 9, 2018
Clinical News

FDA approves less frequent dosing for BMS's Opdivo deficient (dMMR) metastatic colorectal cancer (mCRC) that has progressed following treatment with a fluoropyrimidine, oxaliplatin...
BioCentury | Mar 7, 2018
Distillery Therapeutics


...cell line, nitroglycerine plus the generic chemotherapies oxaliplatin and 5-fluorouracil (5-FU) increased apoptosis compared with oxaliplatin... Feb. 5, 2018 doi:10.1158/0008-5472.CAN-17-2078 CONTACT: Stephanie Plenchette, PSL Research University, Paris, France email: Jennie Walters nitroglycerin oxaliplatin Nitric...
BioCentury | Mar 1, 2018
Translation in Brief

A path less traveled

...towards the pro-apoptotic CASP8 pathway, the team wrote in its paper. The team also showed oxaliplatin...
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