BioCentury | Oct 3, 2020
Translation in Brief

A SARS-CoV-2 genome degrader; neutralizing influenza B mAbs; Fulcrum’s sickle cell therapy increases fetal hemoglobin and more

...of the disease and in patient-derived erythroid cells. The company presented the data on the small molecule EED inhibitor...
BioCentury | Dec 5, 2019
Emerging Company Profile

Deerfield propels Civetta with $53M series A

...programs include the chromatin complex regulators EED and WDR5. Novartis AG (NYSE:NVS; SIX:NOVN) has the EED inhibitor...
BioCentury | Mar 10, 2017
Targets & Mechanisms

Poly drugs for polycomb

...they have better potency and selectivity, and are less likely to generate resistance mechanisms. AbbVie’s EED inhibitor...
...antagonist in cellular cancer assays and mouse lymphoma xenograft models. Novartis showed exposure to its EED inhibitor...
...EZH2 inhibitors in a human Non-Hodgkin’s Ki-positive large cell lymphoma cell line. Novartis combined their EED inhibitor...
BioCentury | Mar 9, 2017
Distillery Therapeutics


INDICATION: Lymphoma Cell culture and mouse studies suggest allosteric inhibition of the EED subunit of PRC2 could help treat lymphoma. Screening of small molecule libraries in in vitro activity assays by two independent groups yielded...
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