BC Innovations | Nov 1, 2012
Cover Story

Revving up glycolysis

A trio of papers has provided new hints into how best to use small molecule activators of pyruvate kinase M2 isozyme , a cancer metabolism enzyme present nearly universally across tumor types. Based on that research,...
BC Innovations | Nov 1, 2012
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Pyruvate kinase M2 isozyme (PKM2) In vitro and cell culture studies identified a serine-binding, allosteric activation site on PKM2 that could be targeted to...
BC Innovations | Oct 25, 2012
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Pyruvate kinase M2 isozyme (PKM2) In vitro and cell culture studies suggest PKM2 activators could help treat cancers with low tumor serine levels. High...
BC Innovations | Oct 11, 2012
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Pyruvate kinase M2 isozyme (PKM2) Cell culture and mouse studies suggest PKM2 activators could help treat cancer. In a lung cancer cell line grown...
BC Innovations | Dec 1, 2011
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Pyruvate kinase M2 isozyme (PKM2); b-catenin (CTNNB1) A study in mice and in cell culture suggests antagonizing interactions between PKM2 and CTNNB1 could...
BC Innovations | Nov 17, 2011
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Pyruvate kinase M2 isozyme (PKM2) Mouse and cell culture studies suggest PKM2 activators could block an antioxidant mechanism to help...
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