14:43 , Dec 11, 2018 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Myocardial infarction (MI) Cell culture and mouse studies identified a pyrimidinone-based inhibitor of TLR4 that could help treat MI. Chemical synthesis and screening of peptidomimetic analogs of a previously identified TLR4 inhibitor peptide in...
20:32 , May 23, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Cardiovascular Patient sample and mouse studies suggest inhibiting TLR4 signaling could help treat cerebral cavernous malformation (CCM). In 188 patients with familial CCM, two SNPs on TLR4 (rs10759930 and rs10759931) were associated with high...
15:56 , Apr 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Pulmonary

INDICATION: Pulmonary fibrosis Mouse studies suggest the cucurbitane analog mogroside IIIE and other TLR4 inhibitors could help treat pulmonary fibrosis. In primary lung fibroblasts from a mouse model of the disease, mogroside IIIE decreased fibroblast...
07:00 , May 16, 2013 |  BC Innovations  |  Cover Story

Eritoran insight for influenza treatment

A University of Maryland School of Medicine team has used a toll-like receptor 4 antagonist to treat influenza in mice. 1 The results provide a repurposing opportunity for Eisai Co. Ltd. 's toll-like receptor 4...