BC Innovations | Oct 16, 2014
Cover Story

DisABLing imatinib

Mutations in BCR-ABL tyrosine kinase have long been associated with resistance to Gleevec imatinib, but they only account for about half of all cases. University of Massachusetts researchers have shown that upregulation of protein kinase...
BC Innovations | Jun 12, 2014
Targets & Mechanisms

Putting SMYD3 on the MAP

Stanford University and GlaxoSmithKline plc researchers have uncovered the mechanism of action of SMYD3 , a histone lysine methyltransferase overexpressed in many lung and pancreatic tumors. 1 The surprise was that SMYD3 acts in the cytoplasm...
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