BioCentury | May 1, 2014
Distillery Therapeutics

Indication: Neurology

...information Neurology Spinal cord injury (SCI) Chondroitin sulfate proteoglycan (CSPG) Rat studies suggest lentivirus-delivered, mammalian-optimized chondroitinase...
BioCentury | Mar 6, 2014
Distillery Therapeutics

Indication: Neurology

...were engineered to coexpress a bifunctional neurotrophin that activates TrkB and TrkC and a bacterial chondroitinase...
...component CSPG. In a rat model of SCI, transplanted Schwann cells expressing the neurotrophin and chondroitinase...
...could include developing methods for autologous transplantation of patient-derived Schwann cells. Acorda Therapeutics Inc. has chondroitinase...
BioCentury | Jul 28, 2011
Distillery Therapeutics

Indication: Neurology

...CSPGs could improve recovery following SCI. In a rat SCI model, peripheral nerve autograft plus chondroitinase...
...comment on its next steps. SciBX 4(29); doi:10.1038/scibx.2011.831 Published online July 28, 2011 Use of chondroitinase...
BioCentury | Jul 1, 2010
Targets & Mechanisms

Neuraminidase for spinal cord injury

...4 ( RTN4 ; NOGO-A ; NOGO ), is in Phase I testing for SCI. Chondroitinase...
...Combinatorial potential Schnaar's group is now evaluating the use of recombinant neuraminidase plus a research-grade chondroitinase...
...model. He said his team also is considering combining the neuraminidase with anti-NOGO therapies. The chondroitinase...
BioCentury | Jun 17, 2010
Distillery Therapeutics

Indication: Neurology

...other compounds in development to treat SCI, including the recombinant enzyme chondroitinase. Acorda Therapeutics Inc.'s chondroitinase...
BioCentury | Apr 15, 2010
Targets & Mechanisms

Axon-regenerating small molecules

...RTN4 ; NOGO-A ; NOGO ), a component of myelin, whereas Acorda Therapeutics Inc. 's chondroitinase...
BioCentury | Feb 11, 2010
Distillery Therapeutics

Indication: Neurology

...injury (SCI) Chondroitin sulfate proteoglycans (CSPGs) A study in rats suggests that digesting CSPGs with chondroitinase...
BioCentury | Nov 5, 2009
Cover Story

Unblocking axonal regeneration

...using a bacterial enzyme called chondroitinase that digests CSPGs at the site of CNS lesions. Chondroitinase...
...limitations in SCI, according to Silver, who was a principal investigator on the Science paper. "Chondroitinase...
...at the mammalian lesion site, leading to a very short half-life," he said. "Also, delivering chondroitinase...
BioCentury | Oct 9, 2008
Targets & Mechanisms

In the mood for regeneration

...larger animal models of spinal cord injury, such as cats or even primates." Acorda's recombinant chondroitinase...
...has shown that lithium plus chondroitinase enhanced the axonal regeneration compared with the effects of chondroitinase...
...NASDAQ:ASTM) Neural repair cells (NRCs) NRCs based on Tissue Repair Cell (TRC) technology Preclinical Acorda Chondroitinase...
BioCentury | May 22, 2006
Tools & Techniques

Envisioning plasticity

...Italian researchers have shown that surgery plus injections of chondroitinase ABC (chABC), an enzyme that degrades...
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