07:00 , May 1, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Spinal cord injury (SCI) Chondroitin sulfate proteoglycan (CSPG) Rat studies suggest lentivirus-delivered, mammalian-optimized chondroitinase ABC (ChABC) could help treat SCI. Levels of extracellular matrix-associated CSPGs...
08:00 , Mar 6, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Spinal cord injury (SCI) Neurotrophic tyrosine kinase receptor 2 (NTRK2; TrkB); NTRK3 (TrkC); chondroitin sulfate proteoglycan (CSPG) Studies in rats suggest engineered Schwann cells could...
07:00 , Jul 28, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Spinal cord injury (SCI) Chondroitin sulfate proteoglycan (CSPG) Rat studies suggest a peripheral nerve autograft plus treatment to dissolve CSPGs could improve recovery following SCI....
07:00 , Jul 1, 2010 |  BC Innovations  |  Targets & Mechanisms

Neuraminidase for spinal cord injury

Researchers at The Johns Hopkins University School of Medicine have shown that treatment with a recombinant bacterial neuraminidase can promote the recovery of motor and autonomic function in a rat model of spinal cord contusion...
07:00 , Jun 17, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Spinal cord injury (SCI) Neuraminidase (NEU1; SIAL1) A study in rats suggests that Vibrio cholerae neu1 could improve post-SCI recovery. In a rat model of...
07:00 , Apr 15, 2010 |  BC Innovations  |  Targets & Mechanisms

Axon-regenerating small molecules

Researchers at the University of Miami Miller School of Medicine have identified compounds that can overcome the two main types of signals that inhibit axon growth in a damaged CNS. 1 The compounds reversed the...
08:00 , Feb 11, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Spinal cord injury (SCI) Chondroitin sulfate proteoglycans (CSPGs) A study in rats suggests that digesting CSPGs with chondroitinase ABC (ChABC) followed by transplantation of neural...
08:00 , Nov 5, 2009 |  BC Innovations  |  Cover Story

Unblocking axonal regeneration

For nearly 20 years it has been known that growth-inhibitory molecules called chondroitin sulfate proteoglycans , or CSPGs, are a major impediment to axonal regeneration at sites of CNS injury. However, blocking CSPG signaling to...
07:00 , Oct 9, 2008 |  BC Innovations  |  Targets & Mechanisms

In the mood for regeneration

Researchers at the University of Texas Southwestern Medical Center have found that lithium, the marketed mood stabilizer, might have utility in spinal cord injury, an indication for which there are no approved drugs. 1 In...
07:00 , May 22, 2006 |  BioCentury  |  Tools & Techniques

Envisioning plasticity

Italian researchers have shown that surgery plus injections of chondroitinase ABC (chABC), an enzyme that degrades chondroitin and some closely related proteins, helps recover vision loss in adult rats with amblyopia, or "lazy eye." They...