21:40 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Sarcoma Cell culture and mouse studies suggest combining Mekinist trametinib with IGF1R inhibitors could help treat PAX3-PAX7 fusion-negative rhabdomyosarcoma. Screening of a panel of 1,912 approved or tool compound small molecule inhibitors in a...
08:00 , Feb 19, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Epidermal growth factor receptor (EGFR); insulin-like growth factor-2 (IGF-2); insulin-like growth factor-1 (IGF-1) receptor (IGF1R; CD221)

Cancer INDICATION: Colorectal cancer In vitro and mouse studies suggest inhibiting IGF-2 signaling could improve the response of IGF-2-overexpressing colon cancers to EGFR inhibitors. In mice bearing patient-derived xenograft colon tumors, high IGF-2 expression was...
08:00 , Dec 15, 2008 |  BioCentury  |  Strategy

BMS cancer pipeline

BMS cancer pipeline...