00:42 , Mar 18, 2016 |  BC Extra  |  Clinical News

Animal data link sclerostin inhibition to joint destruction

A team from the University Hospital Muenster published animal data in Science Translational Medicine that show sclerostin inhibition promotes TNF-dependent joint destruction. In human TNF alpha transgenic (hTNFtg) mice, antibody-mediated inhibition of sclerostin led...