BC Innovations | Mar 13, 2019
Distillery Therapeutics

Inhibiting PIEZO1 for nerve damage

DISEASE CATEGORY: Neurology INDICATION: Nerve damage Fruit fly and mouse studies suggest inhibiting PIEZO1 could help treat nerve damage. In two Drosophila models of sensory nerve injury and one Drosophila model of motor nerve injury,...
BC Innovations | May 9, 2018
Distillery Therapeutics

Gastrointestinal

INDICATION: Pancreatitis Mouse studies suggest PIEZO1 inhibition could help treat pancreatitis. In a mouse model of pressure-induced acute pancreatitis, pancreatic acinar cell-specific knockout of PIEZO1 or the PIEZO1 inhibitor AT-300 decreased histological disease scores and...
BC Week In Review | Mar 24, 2017
Clinical News

HT-100 regulatory update

FDA granted Akashi clearance to resume clinical development of Duchenne muscular dystrophy (DMD) candidate HT-100. The company said it plans to start a new Phase IIa trial “as quickly as possible.” In January 2016, Akashi...
BC Extra | Mar 22, 2017
Clinical News

Akashi restarting development of DMD candidate

Akashi Therapeutics Inc. (Cambridge, Mass.) said FDA granted the company clearance to resume clinical development of Duchenne muscular dystrophy candidate HT-100 . The company said it intends to start a new Phase IIa trial “as quickly...
BC Innovations | Dec 11, 2014
Targets & Mechanisms

PIEZO de resistance

A pair of recently identified calcium channels- PIEZO1 and PIEZO2-control the response of cartilage to heavy loads and offer new targets for joint injury and osteoarthritis, according to findings from a team at Duke University...
BC Innovations | Dec 11, 2014
Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Cartilage repair Piezo-type mechanosensitive ion channel component 1 (PIEZO1); PIEZO2 Cell and tissue culture studies suggest inhibiting PIEZO1 and PIEZO2 could prevent load-induced articular...
BC Week In Review | Jan 8, 2001
Company News

Georgetown University other research news

Researchers used GsMtx-4, a small molecule inhibitor of cationic SACs derived from the venom of the tarantula Grammostola spatulata, to inhibit increases in incidence and duration of atrial fibrillation in rabbit hearts under increased intra-atrial...
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