15:20 , May 9, 2018 |  BC Innovations  |  Distillery Therapeutics

Gastrointestinal

INDICATION: Pancreatitis Mouse studies suggest PIEZO1 inhibition could help treat pancreatitis. In a mouse model of pressure-induced acute pancreatitis, pancreatic acinar cell-specific knockout of PIEZO1 or the PIEZO1 inhibitor AT-300 decreased histological disease scores and levels...
20:17 , Mar 24, 2017 |  BC Week In Review  |  Clinical News

HT-100 regulatory update

FDA granted Akashi clearance to resume clinical development of Duchenne muscular dystrophy (DMD) candidate HT-100. The company said it plans to start a new Phase IIa trial “as quickly as possible.” In January 2016, Akashi...
22:31 , Mar 22, 2017 |  BC Extra  |  Clinical News

Akashi restarting development of DMD candidate

Akashi Therapeutics Inc. (Cambridge, Mass.) said FDA granted the company clearance to resume clinical development of Duchenne muscular dystrophy candidate HT-100. The company said it intends to start a new Phase IIa trial “as quickly...
08:00 , Dec 11, 2014 |  BC Innovations  |  Targets & Mechanisms

PIEZO de resistance

A pair of recently identified calcium channels-PIEZO1 and PIEZO2-control the response of cartilage to heavy loads and offer new targets for joint injury and osteoarthritis, according to findings from a team at Duke University.1 A...
08:00 , Dec 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Cartilage repair Piezo-type mechanosensitive ion channel component 1 (PIEZO1); PIEZO2 Cell and tissue culture studies suggest...
08:00 , Jan 8, 2001 |  BC Week In Review  |  Company News

Georgetown University other research news

Researchers used GsMtx-4, a small molecule inhibitor of cationic SACs derived from the venom of the tarantula Grammostola spatulata, to inhibit increases in incidence and duration of atrial fibrillation in rabbit hearts under increased intra-atrial...