BC Innovations | Jan 17, 2018
Distillery Techniques

Drug platforms

TECHNOLOGY: Structural analyses Structural analyses of active, ligand-bound KOR could guide the design of biased KOR agonists to treat pain. A complex of crystallized KOR and a high-affinity ligand was suspended in a lipid-containing solution...
BC Innovations | Jan 3, 2017
Distillery Therapeutics

Neurology; dermatology

INDICATION: Pain; itch Mouse and rat studies suggest a G protein-biased KOR agonist could help treat pain and itch without the sedation and dysphoria caused by unbiased KOR agonists. A previously reported triazole-based, biased KOR...
BC Innovations | Aug 11, 2016
Distillery Therapeutics

Therapeutics: κ opioid receptor (KOR; OPRK1)

Autoimmune disease INDICATION: Multiple sclerosis Cell culture and mouse studies suggest KOR agonists could help treat MS. In co-cultures of neurons and oligodendrocyte precursor cells (OPCs), a KOR agonist tool compound increased differentiation of OPCs...
BC Week In Review | Jun 22, 2015
Clinical News

Asimadoline: Phase II started

Tioga began a double-blind, placebo-controlled, U.S. Phase II trial to evaluate 5 mg oral asimadoline daily for up to 8 weeks in about 200 patients. Tioga Pharmaceuticals Inc. , San Diego, Calif.   Product: Asimadoline  ...
BioCentury | Feb 10, 2014
Product Development

Furiex's run at IBS-D

While Furiex Pharmaceuticals Inc. has hit its marks in two Phase III studies of eluxadoline to treat diarrhea-predominant irritable bowel syndrome, it is hard to say how the response rates measure up to the only...
BioCentury | Mar 18, 2013
Emerging Company Profile

gIcare: Colonoscopy comfort

gIcare pharma Inc. is developing a pipeline of non-sedating colonic analgesic compounds to provide new and lower cost alternatives for pain management during colonoscopy. Sedation during endoscopy has become routine practice among gastroenterologists, even though...
BioCentury | Jan 7, 2013

Buyside View XXI: Sunny side up

Stephen Hansen Senior Writer  A strong crop of early PDUFA dates and a sense that FDA is more navigable have given money managers in the U.S. and Europe a positive outlook for 2013, which they...
BioCentury | Dec 24, 2012
Emerging Company Profile

Aros: Easing IBS pain

Aros Pharma ApS has found a new way to treat pain associated with irritable bowel syndrome. The company is developing an ASIC1A antagonist that specifically reduces gastrointestinal pain and could be an effective adjunct therapy...
BC Week In Review | Aug 20, 2012
Clinical News

Asimadoline: Phase II started

Ono disclosed in its 1Q12 earnings ending June 30 that it began a double-blind, placebo-controlled, Japanese Phase II trial to evaluate oral asimadoline in about 189 patients. Ono has right to the compound from Tioga...
BC Extra | Apr 13, 2012
Financial News

Tioga raises $10 million in series B

Tioga Pharmaceuticals Inc. (San Diego, Calif.) raised $10 million in a series B round led by new investor Thomas, McNerney & Partners. Existing investor Genesys Capital Partners also participated. Tioga's asimadoline is in the first...
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