23:08 , Mar 20, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Cell culture studies suggest inhibiting CDK9 could help treat castration-resistant prostate cancer (CRPC) that is resistant to BET bromodomain protein inhibitors. In a human BET inhibitor-resistant CRPC cell line, siRNA targeting CDK9...
23:34 , Nov 2, 2017 |  BC Innovations  |  Targets & Mechanisms

Golden State of DUBs

Four papers in the last two weeks describing inhibitors of the ubiquitin-regulating protein USP7 could signal an important breakthrough in the ability to drug DUBs, a class of enzymes that has been stubbornly intractable until...
07:00 , Jun 23, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: BET bromodomain proteins; bromodomain containing 2 (BRD2); BRD3; BRD4; von Hippel-Lindau tumor suppressor (vHL)

Cancer INDICATION: Prostate cancer Cell culture and mouse studies identified a BET bromodomain protein degrader that could help treat castration-resistant prostate cancer (CRPC). Chemical synthesis and testing in three human CRPC cell lines of small...