08:00 , Nov 12, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: MicroRNA-10b (miR-10b)

Cancer In vitro and mouse studies suggest an miR-10b inhibitor plus doxorubicin could help treat metastatic breast cancer. Levels of miR-10b were higher in human metastatic breast cancer cell lines and in primary tumors from patients...
07:00 , Apr 8, 2010 |  BC Innovations  |  Targets & Mechanisms

miRNA inhibition of metastasis

A U.S. team that included researchers from Regulus Therapeutics Inc. has reported the first successful inhibition of a microRNA-^miR-10b-in tumor cells, a feat that previously had only been accomplished in normal tissue.1 The biotech's anti-miRNA...
07:00 , Apr 5, 2010 |  BC Week In Review  |  Clinical News

Regulus preclinical data

In a mouse model of breast cancer, antagomir-10b significantly reduced the number of macroscopically visible pulmonary breast cancer metastases by 86% compared with saline-treated controls (p=0.00005). The antisense oligonucleotide targeting microRNA-10b also significantly reduced...