BioCentury | Nov 27, 2018
Distillery Therapeutics

Cancer

INDICATION: Acute myelogenous leukemia (AML) Cell culture and mouse studies identified an indole-dihydropyrazine-based MCL1 inhibitor that could help treat AML in combination with Venclyxto venetoclax. In mononuclear bone marrow cells from six AML patients who...
BioCentury | Feb 21, 2018
Distillery Therapeutics

Cancer

...176, a MCL1 inhibitor, in Phase I testing for multiple myeloma (MM). Complix N.V. has anti-MCL-1 Alphabody...
BioCentury | Jan 31, 2018
Distillery Therapeutics

Cancer

...MCL1 inhibitor, in Phase I testing to treat relapsed or refractory MM. Complix N.V. has Anti-MCL-1 Alphabody...
BioCentury | Aug 22, 2017
Distillery Therapeutics

Cancer

...in Phase I testing to treat relapsed or refractory multiple myeloma (MM). Complix N.V. has Anti-MCL-1 alphabody...
BioCentury | Sep 22, 2016
Distillery Therapeutics

Therapeutics: Myeloid leukemia cell differentiation protein (MCL1); eukaryotic translation initiation factor 4B (EIF4B)

Cancer INDICATION: Breast cancer Patient sample and cell studies suggest inhibiting EIF4B or MCL1 could help treat basal breast cancer. In tumor samples from breast cancer patients, MCL1 levels were higher in the aggressive basal...
BioCentury | Jun 18, 2015
Distillery Techniques

Techniques: Crystal structure of myeloid leukemia cell differentiation protein (MCL1)

Drug platforms TECHNOLOGY: Crystal structures Crystallographic studies on an MCL1 fusion protein could aid the structure-based design of MCL1-specific inhibitors. A fusion of maltose binding protein and MCL1 containing three mutations to enhance its crystal...
BioCentury | Apr 30, 2015
Distillery Therapeutics

Therapeutics: Myeloid leukemia cell differentiation protein (MCL1); B cell lymphoma 2 (BCL-2; BCL2); Bcl-XL

Cancer INDICATION: Cancer In vitro studies identified a tricyclic indole-based, selective inhibitor of MCL1 that could help treat cancer. Fragment-based drug design, chemical synthesis and in vitro testing of tricyclic 2-indole carboxylic acid analogs identified...
Items per page:
1 - 7 of 7