08:00 , Jan 15, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2; neu)

Cancer INDICATION: Brain cancer Mouse and cell culture studies suggest ANG4043 , a conjugate of the brain-penetrant peptide angiopep-2 and an anti- HER2 mAb, could help treat brain cancer. In mice with HER2-positive brain tumors,...
08:00 , Dec 15, 2014 |  BC Week In Review  |  Clinical News

Angiochem preclinical data

In mice bearing intracranial HER2-positive tumors, twice-weekly 15 mg/kg IV ANG4043 significantly improved median overall survival (OS) vs. vehicle-treated controls (80 vs. 45 days, p=0.0003). Data were published in Molecular Cancer Therapeutics. ANG4043 consists of...