Vor Biopharma unveils lead candidate comprising CD33-deficient stem cells  Vor Biopharma Inc. co-founder Siddhartha Mukherjee at Columbia University showed transplantation of hematopoietic stem cells with genetic ablation of CD33 allowed CAR T or antibody therapy...

New Enterprise Associates has signed onto Metacrine Inc.’s proposition that there is room to improve upon more advanced FXR agonists in development for non-alcoholic steatohepatitis. Metacrine closed an untranched $22 million series B round led...

With new papers published by the day and a flurry of big-dollar deals and financings, it's hard to separate the signal from the noise in the microbiome space. The space has become so hot that...

Synthetic Biologics Inc. (NYSE-M:SYN) fell $0.21 (14%) to $1.28 on Tuesday after it said it terminated a license with the Regents of the University of California to IP covering the use of Trimesta , an oral...

Top-line data from 54 breath methane-positive IBS-C patients in the open-label extension of the double-blind, placebo-controlled, U.S. Phase II SB-2-010-001 trial showed that once-daily 42 mg oral SYN-010 met the primary endpoint of reducing breath...

Top-line data from the double-blind, placebo-controlled, U.S. Phase II SB-2-010-001 trial in 63 breath methane-positive IBS-C patients showed that once-daily 42 mg oral SYN-010 significantly reduced the area under the curve (AUC) of breath methane...

Synthetic began an open-label, U.S. Phase II extension trial to evaluate 42 mg oral SYN-010 once daily for about 2 months in about 60 patients who completed the Phase II SB-2-010-001 trial. Top-line data from...

Synthetic began a double-blind, placebo-controlled, U.S. Phase II trial to evaluate 21 and 42 mg oral SYN-010 once daily for 28 days in about 60 breath methane-positive patients. Synthetic is developing SYN-010 under section 505(b)(2)...

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Ras/RAF/MEK/ERK pathway; Src homology protein tyrosine phosphatase 2 (SHP-2; SHPTP2; PTPN11) Mouse studies suggest inhibiting ERK activity could help treat cognitive deficits in Noonan...

New excluded drugs lists devised by pharmacy benefits managers are raising the hurdle for reimbursement of drugs the PBMs' pharmacy and therapeutics committees consider to be clinically equivalent to cheaper drugs. Drugs that are not...