15:48 , May 24, 2017 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Patient samples, cell culture, and mouse studies suggest P2RX7 inhibitors could help treat diabetic nephropathy. In glomeruli samples from diabetes patients, P2RX7 expression was higher in patients with nephropathy than in patients without renal...
23:07 , Jan 3, 2017 |  BC Innovations  |  Distillery Therapeutics

Inflammation; dermatology; renal

INDICATION: Inflammation; dermatitis; glomerulonephritis Cell culture, human sample and mouse studies identified anti-P2RX7 nanobodies that could help treat allergic contact dermatitis, glomerulonephritis and other inflammatory diseases. Screening of nanobody libraries from P2RX7-immunized llamas, engineering of hits...
07:00 , Jul 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7)

Infectious disease INDICATION: HIV / AIDS Cell culture studies suggest P2RX7 inhibitors or imipramine could help treat HIV infection. In an assay of ATP-stimulated virion release in HIV-infected human macrophage cell lines, a research-grade inhibitor of P2RX7...