21:12 , Jan 23, 2018 |  BC Innovations  |  Distillery Therapeutics

Transplant

INDICATION: Graft rejection Patient sample and mouse studies suggest inhibiting P2RX7 could help treat transplant rejection. In blood samples from liver transplant patients, monocyte levels of P2RX7 were higher in patients who rejected their transplants than...
15:48 , May 24, 2017 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Patient samples, cell culture, and mouse studies suggest P2RX7 inhibitors could help treat diabetic nephropathy. In glomeruli samples from diabetes patients, P2RX7 expression was higher in patients with nephropathy than in patients without renal...
23:07 , Jan 3, 2017 |  BC Innovations  |  Distillery Therapeutics

Inflammation; dermatology; renal

INDICATION: Inflammation; dermatitis; glomerulonephritis Cell culture, human sample and mouse studies identified anti-P2RX7 nanobodies that could help treat allergic contact dermatitis, glomerulonephritis and other inflammatory diseases. Screening of nanobody libraries from P2RX7-immunized llamas, engineering of hits...
07:00 , Jul 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7)

Infectious disease INDICATION: HIV / AIDS Cell culture studies suggest P2RX7 inhibitors or imipramine could help treat HIV infection. In an assay of ATP-stimulated virion release in HIV-infected human macrophage cell lines, a research-grade inhibitor of P2RX7...
07:00 , May 17, 2012 |  BC Innovations  |  Targets & Mechanisms

Paradoxical P2X7

Italian researchers have shown in vivo that inhibiting the P2X7 receptor, rather than agonizing it as previously thought, can treat cancer.1 The findings could open up a new disease area for companies developing P2X7 antagonists...
07:00 , May 3, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7) Mouse studies suggest inhibiting P2X7 could help...
07:00 , Apr 5, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7) Mouse and human studies suggest inhibiting P2X7...
08:00 , Jan 5, 2012 |  BC Innovations  |  Cover Story

No place like inflammasome

Researchers at Virginia Commonwealth University have found that inhibiting inflammasome formation with antagonists of the membrane receptor P2X7 could help prevent heart failure following acute myocardial infarction.1 The findings point to a repurposing opportunity for...
07:00 , Jun 23, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Arterial thrombosis Purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7) Mouse studies suggest inhibiting P2RX7...