BC Innovations | Nov 19, 2019
Distillery Therapeutics

A vaccine made of red blood cell and tumor cell membranes plus checkpoint blockade for breast cancer, melanoma

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; melanoma Personalized vaccines derived from red blood cells and tumor cells could synergize with checkpoint inhibitors to treat breast cancer and melanoma. The vaccines are created by fusing hemoglobin-depleted...
BC Extra | Sep 10, 2019
Tools & Techniques

Lasker honors creators of Herceptin

This year’s suite of Lasker Foundation awards includes recognition of the scientists that created anti-HER2 mAb Herceptin trastuzumab, one of the first transformative therapies to come out of biotech, and one that remains standard of...
BC Innovations | Aug 29, 2019
Distillery Techniques

Single cell metabolic analysis to predict therapeutic response and identify targets for NSCLC

TECHNIQUES CATEGORY: Assays and screens TECHNOLOGY: Diagnostic assays High-throughput metabolic analysis of single tumor cells from liquid biopsy samples could be used to predict response to therapy and identify targets associated with drug resistance in...
BC Innovations | Aug 23, 2019
Distillery Therapeutics

Hydrogels with montmorillonite could repair bone defects

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Delivering the clay mineral montmorillonite, which could serve as a scaffold for cells, as part of a nanocomposite hydrogel could treat bone defects. The nanocomposite hydrogels are synthesized by...
BC Innovations | Aug 22, 2019
Distillery Techniques

Delivering mAbs to CNS metastases using polymer-based nanoparticles

TECHNIQUES CATEGORY: Drug delivery TECHNOLOGY: Polymers; nanoparticles A zwitterionic polymer-based nanoparticle system could enable delivery of therapeutic mAbs to cancer metastases in the CNS. The method involves encapsulating mAbs in nanoparticles formed by cross-linking methacryloyloxyethyl...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

LIF-expressing myeloid cells for DMD

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular dystrophy LIF-expressing myeloid cells could help treat Duchenne muscular dystrophy (DMD). Bone-marrow derived macrophages, which infiltrate dystrophic muscle tissue, isolated from mice overexpressing human LIF in myeloid cells exhibited lower...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

Glucose-responsive insulin delivery for diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes A UCLA and North Carolina State University team funded by JDRF and Sanofi developed a charge-switchable polymer complex that could help treat diabetes by automatically delivering insulin in response to...
BC Extra | Aug 6, 2019
Company News

Management tracks: Allogene snags Adaptimmune's Amado; plus Foundation Medicine, CymaBay and more

CAR T therapy company Allogene Therapeutics Inc . (NASDAQ:ALLO) hired Rafael G. Amado as EVP of R&D and CMO, effective Sept. 3. He was president of R&D at Adaptimmune Therapeutics plc (NASDAQ:ADAP). Allogene Executive Chairman and...
BC Innovations | Aug 2, 2019
Translation in Brief

A charged system for insulin delivery

A charge-based glucose-binding switch is the latest technology aimed at enabling automatic insulin control. With proof-of-concept experiments in mice and minipigs, the system could rival preclinical technologies picked up by Eli Lilly, Merck and Novo...
BC Innovations | Aug 1, 2019
Distillery Therapeutics

Tumor-penetrating camptothecin conjugate for liver, pancreatic cancers

DISEASE CATEGORY: Cancer INDICATION: Liver cancer; pancreatic cancer A team led by ZenCapsule Inc. scientific co-founder Zhen Gu showed that a tumor-penetrating polymeric camptothecin conjugate could treat liver and pancreatic cancers. The conjugate consists of...
Items per page:
1 - 10 of 493
BC Innovations | Nov 19, 2019
Distillery Therapeutics

A vaccine made of red blood cell and tumor cell membranes plus checkpoint blockade for breast cancer, melanoma

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; melanoma Personalized vaccines derived from red blood cells and tumor cells could synergize with checkpoint inhibitors to treat breast cancer and melanoma. The vaccines are created by fusing hemoglobin-depleted...
BC Extra | Sep 10, 2019
Tools & Techniques

Lasker honors creators of Herceptin

This year’s suite of Lasker Foundation awards includes recognition of the scientists that created anti-HER2 mAb Herceptin trastuzumab, one of the first transformative therapies to come out of biotech, and one that remains standard of...
BC Innovations | Aug 29, 2019
Distillery Techniques

Single cell metabolic analysis to predict therapeutic response and identify targets for NSCLC

TECHNIQUES CATEGORY: Assays and screens TECHNOLOGY: Diagnostic assays High-throughput metabolic analysis of single tumor cells from liquid biopsy samples could be used to predict response to therapy and identify targets associated with drug resistance in...
BC Innovations | Aug 23, 2019
Distillery Therapeutics

Hydrogels with montmorillonite could repair bone defects

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Delivering the clay mineral montmorillonite, which could serve as a scaffold for cells, as part of a nanocomposite hydrogel could treat bone defects. The nanocomposite hydrogels are synthesized by...
BC Innovations | Aug 22, 2019
Distillery Techniques

Delivering mAbs to CNS metastases using polymer-based nanoparticles

TECHNIQUES CATEGORY: Drug delivery TECHNOLOGY: Polymers; nanoparticles A zwitterionic polymer-based nanoparticle system could enable delivery of therapeutic mAbs to cancer metastases in the CNS. The method involves encapsulating mAbs in nanoparticles formed by cross-linking methacryloyloxyethyl...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

LIF-expressing myeloid cells for DMD

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular dystrophy LIF-expressing myeloid cells could help treat Duchenne muscular dystrophy (DMD). Bone-marrow derived macrophages, which infiltrate dystrophic muscle tissue, isolated from mice overexpressing human LIF in myeloid cells exhibited lower...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

Glucose-responsive insulin delivery for diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes A UCLA and North Carolina State University team funded by JDRF and Sanofi developed a charge-switchable polymer complex that could help treat diabetes by automatically delivering insulin in response to...
BC Extra | Aug 6, 2019
Company News

Management tracks: Allogene snags Adaptimmune's Amado; plus Foundation Medicine, CymaBay and more

CAR T therapy company Allogene Therapeutics Inc . (NASDAQ:ALLO) hired Rafael G. Amado as EVP of R&D and CMO, effective Sept. 3. He was president of R&D at Adaptimmune Therapeutics plc (NASDAQ:ADAP). Allogene Executive Chairman and...
BC Innovations | Aug 2, 2019
Translation in Brief

A charged system for insulin delivery

A charge-based glucose-binding switch is the latest technology aimed at enabling automatic insulin control. With proof-of-concept experiments in mice and minipigs, the system could rival preclinical technologies picked up by Eli Lilly, Merck and Novo...
BC Innovations | Aug 1, 2019
Distillery Therapeutics

Tumor-penetrating camptothecin conjugate for liver, pancreatic cancers

DISEASE CATEGORY: Cancer INDICATION: Liver cancer; pancreatic cancer A team led by ZenCapsule Inc. scientific co-founder Zhen Gu showed that a tumor-penetrating polymeric camptothecin conjugate could treat liver and pancreatic cancers. The conjugate consists of...
Items per page:
1 - 10 of 493