BioCentury | Jun 25, 2020
Finance

Autobahn Labs bringing industrial translation to academic projects via joint ownership model, starting with UCLA

Virtual incubator Autobahn Labs aims to industrialize academic projects deemed too early for traditional tech transfer by running them through Evotec’s drug discovery funnel, with the goal of creating jointly owned spinouts backed by Autobahn’s...
BioCentury | May 23, 2020
Translation in Brief

A three-compound dengue treatment; plus reversing antibiotic resistance, AbCellera-Lilly, reducing cholesterol with CRISPR and COVID cash for Sherlock

Hindering dengue by combining host- and virus-targeted drugs  In a Cell Chemical Biology article , Stanford University scientists combined two host-targeted compounds with a virus-targeted compound to yield potent dengue treatment. A DHODH inhibitor tool compound,...
BioCentury | Apr 16, 2020
Translation in Brief

SARS-CoV-2 fluorescent tool for drug development; plus Alzheimer's biomarkers, Nature, National Academies and Pylum

DNA-based tool for developing COVID-19 countermeasures University of Texas Medical Branch researchers have created a fluorescent SARS-CoV-2 DNA clone as a reporter tool for preclinically assessing COVID-19 vaccines and treatments. Described in Cell Host and...
BC Innovations | Nov 19, 2019
Distillery Therapeutics

A vaccine made of red blood cell and tumor cell membranes plus checkpoint blockade for breast cancer, melanoma

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; melanoma Personalized vaccines derived from red blood cells and tumor cells could synergize with checkpoint inhibitors to treat breast cancer and melanoma. The vaccines are created by fusing hemoglobin-depleted...
BC Extra | Sep 10, 2019
Tools & Techniques

Lasker honors creators of Herceptin

This year’s suite of Lasker Foundation awards includes recognition of the scientists that created anti-HER2 mAb Herceptin trastuzumab, one of the first transformative therapies to come out of biotech, and one that remains standard of...
BC Innovations | Aug 29, 2019
Distillery Techniques

Single cell metabolic analysis to predict therapeutic response and identify targets for NSCLC

TECHNIQUES CATEGORY: Assays and screens TECHNOLOGY: Diagnostic assays High-throughput metabolic analysis of single tumor cells from liquid biopsy samples could be used to predict response to therapy and identify targets associated with drug resistance in...
BC Innovations | Aug 23, 2019
Distillery Therapeutics

Hydrogels with montmorillonite could repair bone defects

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Delivering the clay mineral montmorillonite, which could serve as a scaffold for cells, as part of a nanocomposite hydrogel could treat bone defects. The nanocomposite hydrogels are synthesized by...
BC Innovations | Aug 22, 2019
Distillery Techniques

Delivering mAbs to CNS metastases using polymer-based nanoparticles

TECHNIQUES CATEGORY: Drug delivery TECHNOLOGY: Polymers; nanoparticles A zwitterionic polymer-based nanoparticle system could enable delivery of therapeutic mAbs to cancer metastases in the CNS. The method involves encapsulating mAbs in nanoparticles formed by cross-linking methacryloyloxyethyl...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

LIF-expressing myeloid cells for DMD

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular dystrophy LIF-expressing myeloid cells could help treat Duchenne muscular dystrophy (DMD). Bone-marrow derived macrophages, which infiltrate dystrophic muscle tissue, isolated from mice overexpressing human LIF in myeloid cells exhibited lower...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

Glucose-responsive insulin delivery for diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes A UCLA and North Carolina State University team funded by JDRF and Sanofi developed a charge-switchable polymer complex that could help treat diabetes by automatically delivering insulin in response to...
Items per page:
1 - 10 of 496
BioCentury | Jun 25, 2020
Finance

Autobahn Labs bringing industrial translation to academic projects via joint ownership model, starting with UCLA

Virtual incubator Autobahn Labs aims to industrialize academic projects deemed too early for traditional tech transfer by running them through Evotec’s drug discovery funnel, with the goal of creating jointly owned spinouts backed by Autobahn’s...
BioCentury | May 23, 2020
Translation in Brief

A three-compound dengue treatment; plus reversing antibiotic resistance, AbCellera-Lilly, reducing cholesterol with CRISPR and COVID cash for Sherlock

Hindering dengue by combining host- and virus-targeted drugs  In a Cell Chemical Biology article , Stanford University scientists combined two host-targeted compounds with a virus-targeted compound to yield potent dengue treatment. A DHODH inhibitor tool compound,...
BioCentury | Apr 16, 2020
Translation in Brief

SARS-CoV-2 fluorescent tool for drug development; plus Alzheimer's biomarkers, Nature, National Academies and Pylum

DNA-based tool for developing COVID-19 countermeasures University of Texas Medical Branch researchers have created a fluorescent SARS-CoV-2 DNA clone as a reporter tool for preclinically assessing COVID-19 vaccines and treatments. Described in Cell Host and...
BC Innovations | Nov 19, 2019
Distillery Therapeutics

A vaccine made of red blood cell and tumor cell membranes plus checkpoint blockade for breast cancer, melanoma

DISEASE CATEGORY: Cancer INDICATION: Breast cancer; melanoma Personalized vaccines derived from red blood cells and tumor cells could synergize with checkpoint inhibitors to treat breast cancer and melanoma. The vaccines are created by fusing hemoglobin-depleted...
BC Extra | Sep 10, 2019
Tools & Techniques

Lasker honors creators of Herceptin

This year’s suite of Lasker Foundation awards includes recognition of the scientists that created anti-HER2 mAb Herceptin trastuzumab, one of the first transformative therapies to come out of biotech, and one that remains standard of...
BC Innovations | Aug 29, 2019
Distillery Techniques

Single cell metabolic analysis to predict therapeutic response and identify targets for NSCLC

TECHNIQUES CATEGORY: Assays and screens TECHNOLOGY: Diagnostic assays High-throughput metabolic analysis of single tumor cells from liquid biopsy samples could be used to predict response to therapy and identify targets associated with drug resistance in...
BC Innovations | Aug 23, 2019
Distillery Therapeutics

Hydrogels with montmorillonite could repair bone defects

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Delivering the clay mineral montmorillonite, which could serve as a scaffold for cells, as part of a nanocomposite hydrogel could treat bone defects. The nanocomposite hydrogels are synthesized by...
BC Innovations | Aug 22, 2019
Distillery Techniques

Delivering mAbs to CNS metastases using polymer-based nanoparticles

TECHNIQUES CATEGORY: Drug delivery TECHNOLOGY: Polymers; nanoparticles A zwitterionic polymer-based nanoparticle system could enable delivery of therapeutic mAbs to cancer metastases in the CNS. The method involves encapsulating mAbs in nanoparticles formed by cross-linking methacryloyloxyethyl...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

LIF-expressing myeloid cells for DMD

DISEASE CATEGORY: Musculoskeletal INDICATION: Muscular dystrophy LIF-expressing myeloid cells could help treat Duchenne muscular dystrophy (DMD). Bone-marrow derived macrophages, which infiltrate dystrophic muscle tissue, isolated from mice overexpressing human LIF in myeloid cells exhibited lower...
BC Innovations | Aug 8, 2019
Distillery Therapeutics

Glucose-responsive insulin delivery for diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes A UCLA and North Carolina State University team funded by JDRF and Sanofi developed a charge-switchable polymer complex that could help treat diabetes by automatically delivering insulin in response to...
Items per page:
1 - 10 of 496