AC Immune believes it has hit on a breakthrough in vaccine technology with its Alzheimer’s candidate ACI-35. The rest of the world will have to wait to evaluate the claim, as the company and partner...

DISEASE CATEGORY: Cancer INDICATION: Breast Cancer Liposomes formulated to display the apoptosis inducer TRAIL and the tumor-binding adhesion molecule SELE could treat triple-negative breast cancer (TNBC) and prevent metastases following tumor resection. When administered to...

TECHNIQUES CATEGORY: Drug delivery TECHNOLOGY: Nanoparticles Dual-targeting liposomes could be used to deliver cancer therapies. Generation of the liposomes involves two steps: screening human cancer cell lines against a 68-gene panel of common cancer targets...

INDICATION: Brain cancer Mouse studies suggest transferrin-conjugated liposomal nanoparticles loaded with temozolomide and an inhibitor of BET bromodomain proteins could help treat glioma. The liposomal nanoparticles contain distearoylglycerophosphoethanolamine (DSPE) conjugated to polyethylene glycol (PEG) and...

INDICATION: Breast cancer; brain cancer; solid tumors Mouse studies suggest liposomal nanoparticles loaded with immunomodulatory agents could enhance the efficacy of CAR T therapies to treat solid cancers. The liposomal nanoparticles are coated with an...

TECHNOLOGY: Cell-free assays; diagnostic assays An assay for detecting GPC1 mRNA in serum extracellular vesicles could help diagnose PDAC. The assay involves adding patient serum samples to a slide coated with cationic liposomes loaded with...

INDICATION: Inflammation Cell culture and mouse studies suggest photosynthetic hydrogen-generating liposomes could help treat inflammation. The liposomes were loaded with three components: the red light photosensitizer chlorophyll a ; the proton donor ascorbic acid; and...

TECHNOLOGY: Nanoparticles Estrone-conjugated liposomes could be used to deliver therapies to ESR1 -positive tumors. The liposomes are composed of distearoylglycerophosphoethanolamine (DSPE) conjugated to polyethylene glycol (PEG) and the ESR1 ligand estrone and loaded with a...