The Allen Institute expects its latest research endeavor to generate knowledge about molecular drivers of immune-related diseases, paving the way for new diagnostics and therapies. The Allen Institute for Immunology launched on Dec. 12 with...

The Allen Institute expects its latest research endeavor to generate knowledge about molecular drivers of immune-related diseases, paving the way for new diagnostics and therapies. The Allen Institute for Immunology launched Wednesday with $125 million...

The MedImmune LLC unit of AstraZeneca plc thinks its pipeline of immune stimulators will give it an edge in the crowded field of neoantigen cancer vaccines. The company's strategy raises the question of whether the...

A UCSD group has added "transmissible ER stress (TERS)" to the list of cancer's survival strategies. In a study published this month in Science Signaling , the group showed cancer cells undergoing ER stress send soluble...

Last year’s flurry of interest from tech titans has brought a wealth of new funding to translational science that is gaining them status as new and important players in the biotech ecosystem. With a heavy...

Based on unmet need alone, hearing loss should have been every bit as attractive to investors and drug developers as ophthalmic diseases, which entered a renaissance in the mid-2000s resulting in a multibillion-dollar market for...

Biomarkers that could stratify patients, point to treatment combinations or predict toxicity were a major part of the conversation at this year’s AACR conference, where they emerged as potential difference makers for a range of...

A Science Translational Medicine study has established a quantitative metric of drug cardiotoxicity in human-derived cardiomyocytes, and identified insulin-based strategies to alleviate the cardiotoxicity of certain tyrosine kinase inhibitors (TKIs). Study leader Joseph Wu said...

Three independent teams have demonstrated three different ways of using CRISPR to treat sickle cell disease, paving the way for correcting genetic mutations in a disease where the only long-term therapeutic option is blood transplants...

In settling the question of how Biogen Inc. 's Tecfidera dimethyl fumarate (DMF) acts in multiple sclerosis, a Scripps team has identified PKCθ as a key driver, sitting atop an NF-κB pathway to immunosuppression. The...