BioCentury | Dec 1, 2020
Product Development

Nov. 30 Quick Takes: Grail piloting blood test in U.K.; plus Rhythm, Kadmon, venture rounds for Adrenomed, Xbiome, Transition

...Leptin receptorMC4R – Melanocortin 4 receptorPCSK1 - Proprotein convertase subtilisin/kexin type 1POMC - ProopiomelanocortinROCK2 - Rho-associated...
BioCentury | May 22, 2020
Product Development

May 21 Quick Takes: EC approves Zolgensma for SMA; plus Sunovion, Kadmon, Sorrento, tafasitamab, Zentalis’ new JV

...Btk - Bruton’s tyrosine kinase EGFR (ErbB1; HER1) - Epidermal growth factor receptor ROCK2 - Rho-associated...
...Inc. Novartis AG AveXis Inc. Incyte Corp. MorphoSys AG Zentalis Pharmaceuticals Inc. Bruton's tyrosine kinase (Btk) Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) Rho-associated...
BioCentury | Feb 1, 2020
Preclinical News

Preclinical Roundup: CureVac gets CEPI funding for 2019 coronavirus; plus blockade of CD47-SIRPA for atherosclerosis, Stanford and IBM-CDHI

...to 33 previously published data sets, CytoTRACE predictions correlated well with reported differentiation states (Spearman rho=0.72...
BioCentury | Nov 22, 2019
Preclinical News

Nov. 21 Preclinical Quick Takes: Excision applies CRISPR editing to herpes, John Cunningham viruses; plus Caribou, Oligomerix, Kymab and Gladstone-Boston Univer

...CRISPR-associated protein 3; Cas9 - CRISPR-associated protein 9; CDH1 (CD324) - E-cadherin; ROCK1 - Rho-associated...
BioCentury | Nov 12, 2019
Clinical News

Early success in GvHD sets up NDA for Kadmon’s lead

...other drug, Imbruvica ibrutinib, is marketed to treat the indication. Sandi Wong, Staff Writer KD025, slx-2119 Kadmon Holdings Inc. Rho-associated...
BioCentury | Sep 27, 2019
Preclinical News

Sept. 26 Preclinical Quick Takes: $30M for new lung disease lab; plus AI-derived compounds from Auransa, Atomwise, and diabetes candidates

...atrophy. Targets: CD126 - Interleukin-6 receptor; CNTF - Ciliary neurotrophic factor; MIRO1 (RHOT1) - Mitochondrial Rho...
...Medical Research Bayer AG Brigham and Women's Hospital Massachusetts General Hospital Ciliary neurotrophic factor (CNTF) receptor Interleukin-6 (IL-6) receptor (CD126) Mitochondrial Rho...
BioCentury | Aug 15, 2019
Distillery Therapeutics

TMED9 inhibition for mucin 1 kidney disease

...The TMED9 inhibitor also produced misfolded protein removal from cells expressing mutant UMOD or mutant RHO...
...TARGET/MARKER/PATHWAY: Mucin 1 (MUC1; CD227); transmembrane p24 trafficking protein 9 (TMED9); uromodulin (UMOD; THP); rhodopsin (RHO...
...Medical School, Boston, Mass. email: agreka@broadinstitute.org Claire Quang Broad Institute of MIT and Harvard Mucin 1 (MUC1) (CD227) Rhodopsin (RHO...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...CHTOP could sensitize ovarian cancer cells to platinum therapy. University of New South Wales Citron rho-interacting...
BioCentury | Mar 13, 2019
Company News

FDA approves Aerie glaucoma therapy Rocklatan

...The product is a fixed-dose combination of Aerie's Rhopressa netarsudil 0.02%, a dual inhibitor of Rho...
...market close, when it announced the approval. Chris Lieu, Staff Writer Rocklatan, Roclatan, netarsudil/latanoprost (PG324) Aerie Pharmaceuticals Inc. Norepinephrine transporter Rho...
BioCentury | Feb 15, 2019
Clinical News

Redx to test antifibrotic in clinic for NASH in 2020

...Redx Pharma plc (LSE:REDX) said its lead Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor reduced...
...its ROCK2 inhibitors to treat NASH in 2020. Redx Pharma plc (LSE:REDX), Liverpool, U.K. Product: Rho-associated...
...coiled-coil containing protein kinase 2 (ROCK2) inhibitor Business: Hepatic Indication: Non-alcoholic steatohepatitis (NASH) Sandi Wong Redx Pharma plc Rho-associated...
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1 - 10 of 357
BioCentury | Dec 1, 2020
Product Development

Nov. 30 Quick Takes: Grail piloting blood test in U.K.; plus Rhythm, Kadmon, venture rounds for Adrenomed, Xbiome, Transition

...Leptin receptorMC4R – Melanocortin 4 receptorPCSK1 - Proprotein convertase subtilisin/kexin type 1POMC - ProopiomelanocortinROCK2 - Rho-associated...
BioCentury | May 22, 2020
Product Development

May 21 Quick Takes: EC approves Zolgensma for SMA; plus Sunovion, Kadmon, Sorrento, tafasitamab, Zentalis’ new JV

...Btk - Bruton’s tyrosine kinase EGFR (ErbB1; HER1) - Epidermal growth factor receptor ROCK2 - Rho-associated...
...Inc. Novartis AG AveXis Inc. Incyte Corp. MorphoSys AG Zentalis Pharmaceuticals Inc. Bruton's tyrosine kinase (Btk) Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) Rho-associated...
BioCentury | Feb 1, 2020
Preclinical News

Preclinical Roundup: CureVac gets CEPI funding for 2019 coronavirus; plus blockade of CD47-SIRPA for atherosclerosis, Stanford and IBM-CDHI

...to 33 previously published data sets, CytoTRACE predictions correlated well with reported differentiation states (Spearman rho=0.72...
BioCentury | Nov 22, 2019
Preclinical News

Nov. 21 Preclinical Quick Takes: Excision applies CRISPR editing to herpes, John Cunningham viruses; plus Caribou, Oligomerix, Kymab and Gladstone-Boston Univer

...CRISPR-associated protein 3; Cas9 - CRISPR-associated protein 9; CDH1 (CD324) - E-cadherin; ROCK1 - Rho-associated...
BioCentury | Nov 12, 2019
Clinical News

Early success in GvHD sets up NDA for Kadmon’s lead

...other drug, Imbruvica ibrutinib, is marketed to treat the indication. Sandi Wong, Staff Writer KD025, slx-2119 Kadmon Holdings Inc. Rho-associated...
BioCentury | Sep 27, 2019
Preclinical News

Sept. 26 Preclinical Quick Takes: $30M for new lung disease lab; plus AI-derived compounds from Auransa, Atomwise, and diabetes candidates

...atrophy. Targets: CD126 - Interleukin-6 receptor; CNTF - Ciliary neurotrophic factor; MIRO1 (RHOT1) - Mitochondrial Rho...
...Medical Research Bayer AG Brigham and Women's Hospital Massachusetts General Hospital Ciliary neurotrophic factor (CNTF) receptor Interleukin-6 (IL-6) receptor (CD126) Mitochondrial Rho...
BioCentury | Aug 15, 2019
Distillery Therapeutics

TMED9 inhibition for mucin 1 kidney disease

...The TMED9 inhibitor also produced misfolded protein removal from cells expressing mutant UMOD or mutant RHO...
...TARGET/MARKER/PATHWAY: Mucin 1 (MUC1; CD227); transmembrane p24 trafficking protein 9 (TMED9); uromodulin (UMOD; THP); rhodopsin (RHO...
...Medical School, Boston, Mass. email: agreka@broadinstitute.org Claire Quang Broad Institute of MIT and Harvard Mucin 1 (MUC1) (CD227) Rhodopsin (RHO...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...CHTOP could sensitize ovarian cancer cells to platinum therapy. University of New South Wales Citron rho-interacting...
BioCentury | Mar 13, 2019
Company News

FDA approves Aerie glaucoma therapy Rocklatan

...The product is a fixed-dose combination of Aerie's Rhopressa netarsudil 0.02%, a dual inhibitor of Rho...
...market close, when it announced the approval. Chris Lieu, Staff Writer Rocklatan, Roclatan, netarsudil/latanoprost (PG324) Aerie Pharmaceuticals Inc. Norepinephrine transporter Rho...
BioCentury | Feb 15, 2019
Clinical News

Redx to test antifibrotic in clinic for NASH in 2020

...Redx Pharma plc (LSE:REDX) said its lead Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor reduced...
...its ROCK2 inhibitors to treat NASH in 2020. Redx Pharma plc (LSE:REDX), Liverpool, U.K. Product: Rho-associated...
...coiled-coil containing protein kinase 2 (ROCK2) inhibitor Business: Hepatic Indication: Non-alcoholic steatohepatitis (NASH) Sandi Wong Redx Pharma plc Rho-associated...
Items per page:
1 - 10 of 357