BioCentury | Mar 12, 2021
Product Development

March 11 Quick Takes: FDA’s ODAC to discuss PD-1/PD-L1 mAbs; plus Lilly, RemeGen, Idorsia and more

...13b OX1R (HCRTR1) – Orexin 1 receptor OX2R (HCRTR2) – Orexin 2 receptorRET – Ret proto-oncogeneROCK2 – Rho-associated...
BioCentury | Feb 24, 2021
Deals

Feb. 23 Quick Takes: BGI raises $300M, plus a $230M C round for Clover, Day One, Waksal’s Graviton, Asalyxa

...– MAP kinaseMEK1 (MAP2K1) –MAP kinase kinase 1MEK2 (MAP2K2) – MAP kinase kinase 2ROCK2 - Rho-associated...
BioCentury | Jan 30, 2021
Distillery Therapeutics

SLC12A5, Rho kinase as targets for mutation-associated intellectual disability

...By Claire Quang, Staff Writer DISEASE CATEGORY: NeurologyINDICATION: Cognitive dysfunctionInhibiting SLC12A5, a cation-Cl− cotransporter, or Rho kinase could treat...
...on average speed of neuroblast migration along the rostral migratory stream (RMS). Also in the model, the Rho...
...pulmonary arterial hypertension (PAH).D. Western Therapeutics Institute Inc. (Tokyo:4576) and Kowa Co. Ltd. market Glantec ripasudil, a Rho...
BioCentury | Dec 1, 2020
Product Development

Nov. 30 Quick Takes: Grail piloting blood test in U.K.; plus Rhythm, Kadmon, venture rounds for Adrenomed, Xbiome, Transition

...Leptin receptorMC4R – Melanocortin 4 receptorPCSK1 - Proprotein convertase subtilisin/kexin type 1POMC - ProopiomelanocortinROCK2 - Rho-associated...
BioCentury | May 22, 2020
Product Development

May 21 Quick Takes: EC approves Zolgensma for SMA; plus Sunovion, Kadmon, Sorrento, tafasitamab, Zentalis’ new JV

...Btk - Bruton’s tyrosine kinase EGFR (ErbB1; HER1) - Epidermal growth factor receptor ROCK2 - Rho-associated...
...Inc. Novartis AG Incyte Corp. MorphoSys AG AveXis Inc. Zentalis Pharmaceuticals Inc. Bruton's tyrosine kinase (Btk) Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) Rho-associated...
BioCentury | Feb 1, 2020
Preclinical News

Preclinical Roundup: CureVac gets CEPI funding for 2019 coronavirus; plus blockade of CD47-SIRPA for atherosclerosis, Stanford and IBM-CDHI

...to 33 previously published data sets, CytoTRACE predictions correlated well with reported differentiation states (Spearman rho=0.72...
BioCentury | Nov 22, 2019
Preclinical News

Nov. 21 Preclinical Quick Takes: Excision applies CRISPR editing to herpes, John Cunningham viruses; plus Caribou, Oligomerix, Kymab and Gladstone-Boston Univer

...CRISPR-associated protein 3; Cas9 - CRISPR-associated protein 9; CDH1 (CD324) - E-cadherin; ROCK1 - Rho-associated...
BioCentury | Nov 12, 2019
Clinical News

Early success in GvHD sets up NDA for Kadmon’s lead

...other drug, Imbruvica ibrutinib, is marketed to treat the indication. Sandi Wong, Staff Writer KD025, slx-2119 Kadmon Holdings Inc. Rho-associated...
BioCentury | Sep 27, 2019
Preclinical News

Sept. 26 Preclinical Quick Takes: $30M for new lung disease lab; plus AI-derived compounds from Auransa, Atomwise, and diabetes candidates

...atrophy. Targets: CD126 - Interleukin-6 receptor; CNTF - Ciliary neurotrophic factor; MIRO1 (RHOT1) - Mitochondrial Rho...
...Medical Research Bayer AG Brigham and Women's Hospital Massachusetts General Hospital Ciliary neurotrophic factor (CNTF) receptor Interleukin-6 (IL-6) receptor (CD126) Mitochondrial Rho...
BioCentury | Aug 15, 2019
Distillery Therapeutics

TMED9 inhibition for mucin 1 kidney disease

...The TMED9 inhibitor also produced misfolded protein removal from cells expressing mutant UMOD or mutant RHO...
...TARGET/MARKER/PATHWAY: Mucin 1 (MUC1; CD227); transmembrane p24 trafficking protein 9 (TMED9); uromodulin (UMOD; THP); rhodopsin (RHO...
...Medical School, Boston, Mass. email: agreka@broadinstitute.org Claire Quang Broad Institute of MIT and Harvard Mucin 1 (MUC1) (CD227) Rhodopsin (RHO...
Items per page:
1 - 10 of 360
BioCentury | Mar 12, 2021
Product Development

March 11 Quick Takes: FDA’s ODAC to discuss PD-1/PD-L1 mAbs; plus Lilly, RemeGen, Idorsia and more

...13b OX1R (HCRTR1) – Orexin 1 receptor OX2R (HCRTR2) – Orexin 2 receptorRET – Ret proto-oncogeneROCK2 – Rho-associated...
BioCentury | Feb 24, 2021
Deals

Feb. 23 Quick Takes: BGI raises $300M, plus a $230M C round for Clover, Day One, Waksal’s Graviton, Asalyxa

...– MAP kinaseMEK1 (MAP2K1) –MAP kinase kinase 1MEK2 (MAP2K2) – MAP kinase kinase 2ROCK2 - Rho-associated...
BioCentury | Jan 30, 2021
Distillery Therapeutics

SLC12A5, Rho kinase as targets for mutation-associated intellectual disability

...By Claire Quang, Staff Writer DISEASE CATEGORY: NeurologyINDICATION: Cognitive dysfunctionInhibiting SLC12A5, a cation-Cl− cotransporter, or Rho kinase could treat...
...on average speed of neuroblast migration along the rostral migratory stream (RMS). Also in the model, the Rho...
...pulmonary arterial hypertension (PAH).D. Western Therapeutics Institute Inc. (Tokyo:4576) and Kowa Co. Ltd. market Glantec ripasudil, a Rho...
BioCentury | Dec 1, 2020
Product Development

Nov. 30 Quick Takes: Grail piloting blood test in U.K.; plus Rhythm, Kadmon, venture rounds for Adrenomed, Xbiome, Transition

...Leptin receptorMC4R – Melanocortin 4 receptorPCSK1 - Proprotein convertase subtilisin/kexin type 1POMC - ProopiomelanocortinROCK2 - Rho-associated...
BioCentury | May 22, 2020
Product Development

May 21 Quick Takes: EC approves Zolgensma for SMA; plus Sunovion, Kadmon, Sorrento, tafasitamab, Zentalis’ new JV

...Btk - Bruton’s tyrosine kinase EGFR (ErbB1; HER1) - Epidermal growth factor receptor ROCK2 - Rho-associated...
...Inc. Novartis AG Incyte Corp. MorphoSys AG AveXis Inc. Zentalis Pharmaceuticals Inc. Bruton's tyrosine kinase (Btk) Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) Rho-associated...
BioCentury | Feb 1, 2020
Preclinical News

Preclinical Roundup: CureVac gets CEPI funding for 2019 coronavirus; plus blockade of CD47-SIRPA for atherosclerosis, Stanford and IBM-CDHI

...to 33 previously published data sets, CytoTRACE predictions correlated well with reported differentiation states (Spearman rho=0.72...
BioCentury | Nov 22, 2019
Preclinical News

Nov. 21 Preclinical Quick Takes: Excision applies CRISPR editing to herpes, John Cunningham viruses; plus Caribou, Oligomerix, Kymab and Gladstone-Boston Univer

...CRISPR-associated protein 3; Cas9 - CRISPR-associated protein 9; CDH1 (CD324) - E-cadherin; ROCK1 - Rho-associated...
BioCentury | Nov 12, 2019
Clinical News

Early success in GvHD sets up NDA for Kadmon’s lead

...other drug, Imbruvica ibrutinib, is marketed to treat the indication. Sandi Wong, Staff Writer KD025, slx-2119 Kadmon Holdings Inc. Rho-associated...
BioCentury | Sep 27, 2019
Preclinical News

Sept. 26 Preclinical Quick Takes: $30M for new lung disease lab; plus AI-derived compounds from Auransa, Atomwise, and diabetes candidates

...atrophy. Targets: CD126 - Interleukin-6 receptor; CNTF - Ciliary neurotrophic factor; MIRO1 (RHOT1) - Mitochondrial Rho...
...Medical Research Bayer AG Brigham and Women's Hospital Massachusetts General Hospital Ciliary neurotrophic factor (CNTF) receptor Interleukin-6 (IL-6) receptor (CD126) Mitochondrial Rho...
BioCentury | Aug 15, 2019
Distillery Therapeutics

TMED9 inhibition for mucin 1 kidney disease

...The TMED9 inhibitor also produced misfolded protein removal from cells expressing mutant UMOD or mutant RHO...
...TARGET/MARKER/PATHWAY: Mucin 1 (MUC1; CD227); transmembrane p24 trafficking protein 9 (TMED9); uromodulin (UMOD; THP); rhodopsin (RHO...
...Medical School, Boston, Mass. email: agreka@broadinstitute.org Claire Quang Broad Institute of MIT and Harvard Mucin 1 (MUC1) (CD227) Rhodopsin (RHO...
Items per page:
1 - 10 of 360