BioCentury | Jan 1, 2021
Targets & Mechanisms

A snapshot of target innovation in 2020

...IRE1 (ERN1; IRE1A) - Endoplasmic reticulum to nucleus...
BioCentury | Dec 31, 2020
Distillery Therapeutics

Histamine receptor activation to treat anxiety and OCD

...Writer DISEASE CATEGORY: NeurologyINDICATION: Anxiety; obsessive compulsive disorder (OCD)Activation of histamine receptor HRH3 in the nucleus...
...a selective HRH3 agonist, into the nucleus accumbens reduced anxiety-like behaviors. Photoactivation of histaminergic projections from the tuberomammillary nucleus...
...accumbens reduced anxiety-like behaviors. Photoactivation of histaminergic projections from the tuberomammillary nucleus of the hypothalamus to the nucleus...
BioCentury | Sep 16, 2020
Emerging Company Profile

Graphite launches with $45M series A to use CRISPR-Cas9 for targeted gene integration

...deliver the donor DNA template into the nucleus.”...
...viruses, to get DNA cargo into the nucleus...
BioCentury | May 13, 2020
Emerging Company Profile

QurAlis taking three ALS programs toward clinic with $42M series A

...TDP-43 moves out of a cell’s nucleus, that results in loss of regulation in the nucleus...
BioCentury | May 9, 2020
Deals

Columbia’s peptide nucleic acid technology draws Fortress into rare discovery deal

...with a delivery vehicle that allows the PNAs to cross into cells and into the nucleus...
...delivery and target avidity. “We understood how important the ability to get PNAs to the nucleus...
BioCentury | May 2, 2020
Translation in Brief

ORIC’s CD73 inhibitor for cancer; plus Beam, CRISPR-Cas13 for respiratory infections, COVID-19 complex structure, and more

...Inc., identified a cluster of disease-associated astrocytes (DAAs) in mice with Alzheimer’s disease (AD) using single-nucleus...
BioCentury | Apr 8, 2020
Deals

COVID-19 roundup: U.S. to freeze WHO funding as Wellcome calls on CEOs to support $8B fund; plus Ridgeback-Emory, Karyopharm, IQVia and more

...or refractory multiple myeloma. Because XPO1 facilitates the transport of several viral proteins from the nucleus...
BioCentury | Apr 4, 2020
Product Development

Dealmaking in a pandemic: partnerships speeding COVID-19 countermeasures

...have many of the same benefits, although expression in patient cells requires entry to the nucleus...
BioCentury | Apr 3, 2020
Distillery Therapeutics

Preventing HPV infection with a capsid protein-based peptide

...peptide binds the retromer, a cytoplasmic cellular protein complex that facilitates viral transport to the nucleus...
BioCentury | Apr 3, 2020
Distillery Therapeutics

IRE1 activation to treat cystic fibrosis and Pendred syndrome

...crypt cells as well as CFTR-mediated anion transport in the colon. TARGET/MARKER/PATHWAY: Endoplasmic reticulum to nucleus...
...Lee, Yonsei University College of Medicine, Seoul, South Korea email: mlee@yuhs.ac Claire Quang Yonsei University Endoplasmic reticulum to nucleus...
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1 - 10 of 422
BioCentury | Jan 1, 2021
Targets & Mechanisms

A snapshot of target innovation in 2020

...IRE1 (ERN1; IRE1A) - Endoplasmic reticulum to nucleus...
BioCentury | Dec 31, 2020
Distillery Therapeutics

Histamine receptor activation to treat anxiety and OCD

...Writer DISEASE CATEGORY: NeurologyINDICATION: Anxiety; obsessive compulsive disorder (OCD)Activation of histamine receptor HRH3 in the nucleus...
...a selective HRH3 agonist, into the nucleus accumbens reduced anxiety-like behaviors. Photoactivation of histaminergic projections from the tuberomammillary nucleus...
...accumbens reduced anxiety-like behaviors. Photoactivation of histaminergic projections from the tuberomammillary nucleus of the hypothalamus to the nucleus...
BioCentury | Sep 16, 2020
Emerging Company Profile

Graphite launches with $45M series A to use CRISPR-Cas9 for targeted gene integration

...deliver the donor DNA template into the nucleus.”...
...viruses, to get DNA cargo into the nucleus...
BioCentury | May 13, 2020
Emerging Company Profile

QurAlis taking three ALS programs toward clinic with $42M series A

...TDP-43 moves out of a cell’s nucleus, that results in loss of regulation in the nucleus...
BioCentury | May 9, 2020
Deals

Columbia’s peptide nucleic acid technology draws Fortress into rare discovery deal

...with a delivery vehicle that allows the PNAs to cross into cells and into the nucleus...
...delivery and target avidity. “We understood how important the ability to get PNAs to the nucleus...
BioCentury | May 2, 2020
Translation in Brief

ORIC’s CD73 inhibitor for cancer; plus Beam, CRISPR-Cas13 for respiratory infections, COVID-19 complex structure, and more

...Inc., identified a cluster of disease-associated astrocytes (DAAs) in mice with Alzheimer’s disease (AD) using single-nucleus...
BioCentury | Apr 8, 2020
Deals

COVID-19 roundup: U.S. to freeze WHO funding as Wellcome calls on CEOs to support $8B fund; plus Ridgeback-Emory, Karyopharm, IQVia and more

...or refractory multiple myeloma. Because XPO1 facilitates the transport of several viral proteins from the nucleus...
BioCentury | Apr 4, 2020
Product Development

Dealmaking in a pandemic: partnerships speeding COVID-19 countermeasures

...have many of the same benefits, although expression in patient cells requires entry to the nucleus...
BioCentury | Apr 3, 2020
Distillery Therapeutics

Preventing HPV infection with a capsid protein-based peptide

...peptide binds the retromer, a cytoplasmic cellular protein complex that facilitates viral transport to the nucleus...
BioCentury | Apr 3, 2020
Distillery Therapeutics

IRE1 activation to treat cystic fibrosis and Pendred syndrome

...crypt cells as well as CFTR-mediated anion transport in the colon. TARGET/MARKER/PATHWAY: Endoplasmic reticulum to nucleus...
...Lee, Yonsei University College of Medicine, Seoul, South Korea email: mlee@yuhs.ac Claire Quang Yonsei University Endoplasmic reticulum to nucleus...
Items per page:
1 - 10 of 422