22:22 , Nov 1, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: October 2018

New Therapeutic Targets and Biomarkers: October 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during October. Therapeutic targets are defined as any protein, gene or other molecule...
23:29 , Oct 3, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Frontotemporal dementia Patient sample and fruit fly studies suggest inhibiting ATP5F1B could help treat FUS proteinopathy, a group of neurodegenerative diseases that includes frontotemporal lobe dementia. In postmortem brain samples from patients with FUS-associated...
22:59 , Jul 12, 2018 |  BC Innovations  |  Strategy

HEAL-ing pain at NIH

In a move that could change how pain is studied and treated, NIH is planning a series of projects to build a platform for translational research that is more predictive and reproducible than the current...
12:01 , May 31, 2018 |  BC Extra  |  Company News

Deerfield, Northwestern in translational research pact

In its latest direct investment in academia, Deerfield Management entered a translational research pact with Northwestern University worth up to $65 million. The partners are forming Lakeside Discovery LLC, a JV fashioned on similar partnerships...
22:09 , Apr 12, 2018 |  BC Extra  |  Company News

Management tracks: Verona, Medigene, NeoPhore

Respiratory disease company Verona Pharma plc (LSE:VRP; NASDAQ:VRNA) said CMO Kenneth Newman will resign, effective April 30. The company is seeking a successor. Cancer immunotherapy company Medigene AG (Xetra:MDG1) said CMO and SVP Kai Pinkernell...
17:03 , Feb 6, 2018 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Mouse studies suggest IL-33 could help treat MS. In brain samples from the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, mast cell levels of IL-33 were lower in female mice...
20:01 , Feb 1, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: January 2018

New Therapeutic Targets and Biomarkers: January 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during January 2018. Therapeutic targets are defined as any protein, gene or other...
01:20 , Jan 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Other

INDICATION: Poisoning Cell culture studies suggest inhibiting CYPR, SLC45A4 or ATP7A could help treat paraquat poisoning. Screening of a CRISPR single-guide RNA (sgRNA) library targeting metabolism-related genes in a paraquat-treated human T cell line expressing...
23:39 , Dec 22, 2017 |  BioCentury  |  Regulation

Preference pioneers

Rituxan Hycela subcutaneous rituximab provides the first example of how companies can get patient preference data on an FDA-approved drug label. The new formulation is intended to reduce the treatment burden of rituximab therapy, which...
22:57 , Nov 14, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM) Cell culture and mouse studies suggest inhibiting EZH2 could help treat KDM6A-mutant MM. In three KDM6A-mutant human MM cell lines, two EZH2 inhibitor tool compounds decreased viability and increased apoptosis compared...