ALS TDI said it will evaluate the efficacy of Neurotune's TDI-165 in a preclinical model of amyotrophic lateral sclerosis (ALS). TDI-165 is a biologic targeted at stabilizing the neuromuscular junction. Details were not disclosed. Neurotune...

Neurotune launched NTCAF ELISA to diagnose sarcopenia. The ELISA-based diagnostic for detection of 22kDa C-terminal agrin fragment (CAF) in human serum was developed in collaboration with MicroCoat Biotechnologie GmbH (Bernried, Germany) and the Eureka-Eurostars programme,...

This week in therapeutics Musculoskeletal disease Muscle atrophy Angiotensin II type 1 receptor (AGTR1) A study in mice suggests AGTR1 blockers could help treat muscle atrophy. In mouse models of age- and disuse-related muscle atrophy,...

This week in therapeutics Autoimmune disease Autoimmune disease CD28; inducible T cell co-stimulator ligand (ICOSLG; B7-H2) In vitro and cell culture studies suggest inhibiting interactions between B7-H2 and CD28 could help treat autoimmune disease. An...

Neurotune AG , Schlieren, Switzerland   Business: Neurology, Musculoskeletal   Transitioned: Armin Mader to CEO from CFO; he replaces Executive Chairman Bruno Oesch, who will now focus on strategic and business development  ...

Top-line data from an 8-week, double-blind, placebo-controlled, South African Phase IIa trial in 116 patients showed that dimiracetam was well tolerated at doses of up to 1,600 mg twice daily. There were no significant differences...

Eli Lilly and Co. may have thought FDA had provided a roadmap that would have made Cymbalta duloxetine the first non-opioid and non-NSAID to be approved for a broad label for chronic pain. But the...

University of California, San Francisco researchers have identified the precise spinal cord neurons that cause hypersensitivity to gentle touches, a common form of neuropathic pain associated with injury and inflammation. 1 The study also presents...

Yale University researchers have uncovered a surprising link between Alzheimer's disease and the prion protein that has been linked to mad cow disease and the related human condition, Creutzfeldt-Jakob disease. The team has reported that...

A 2-part, Swiss Phase I trial in 56 healthy volunteers showed that oral dimiracetam was well tolerated. There were no clinically relevant effects of food on pharmacokinetics. The trial consisted of a single-dose assessment of...