06:09 , Mar 19, 2019 |  BC Extra  |  Company News

Tecentriq first front-line extensive-stage SCLC therapy in decades

FDA's approval late Monday of Roche's Tecentriq atezolizumab as front-line treatment for extensive-stage small cell lung cancer marks the first approval of a PD-1/PD-L1 inhibitor in the indication. The drug is also the first initial...
01:35 , Mar 16, 2019 |  BioCentury  |  Politics, Policy & Law

Lukewarm response to cold war on international pricing index

PhRMA and BIO have gone to war against the Trump administration’s proposal to reference some Medicare Part B drug prices to a basket of prices paid in other countries, but they haven’t found many allies...
22:01 , Mar 15, 2019 |  BioCentury  |  Product Development

Broadening the PARP playing field

With its latest clinical win for Lynparza, AstraZeneca is leading the field in stretching the use of PARP inhibitors beyond tumors that carry BRCA mutations. The results highlight one piece of a broader strategy companies...
21:05 , Mar 15, 2019 |  BioCentury  |  Finance

HaiHe's listing recipe

While a recent mega-round raised by HaiHe could position the Shanghai-based company to go public this year, lead investor Huagai Capital is not looking for an exit at least until the company’s first products hit...
02:41 , Mar 15, 2019 |  BC Innovations  |  Product Development

Fresh AIMMs for elite responders

AIMM Therapeutics B.V.’s elite responder platform has identified mAbs that distinguish tumor and healthy cells based on protein modifications. The company is one of a handful of players mining the immune systems of cancer patients...
00:29 , Mar 15, 2019 |  BC Week In Review  |  Clinical News

Syndax pauses entinostat-PD-1/PD-L1 combo program

Syndax said in its 4Q18 financial results that it will "defer advancement" of its program evaluating entinostat plus PD-1/PD-L1 inhibitors after the combinations missed the primary endpoints of improving progression-free survival (PFS) in a pair...
23:03 , Mar 8, 2019 |  BC Extra  |  Company News

Merck partners with King’s College to develop non-opioid pain therapies

Merck has partnered with King's College London to translate research elucidating HCN2 as a pain target to develop non-opioid treatments for chronic neuropathic pain. The deal builds on work from the lab of Peter McNaughton...
18:42 , Mar 8, 2019 |  BC Extra  |  Company News

TNBC gets its first targeted agent with Tecentriq approval

The approval of Roche's Tecentriq atezolizumab to treat metastatic triple-negative breast cancer gives almost half of these patients and physicians' their first agent to treat a molecularly defined subgroup of patients with this fast-progressing cancer....
17:28 , Mar 8, 2019 |  BC Week In Review  |  Clinical News

Keytruda, Inlyta combo improves OS by 47%, PFS by 31% in first-line RCC

Merck & Co. reported detailed data from the Phase III KEYNOTE-426 trial of Keytruda pembrolizumab plus Inlyta axitinib as first-line treatment of renal cell carcinoma. New data showed that the combination significantly improved overall survival...
00:27 , Mar 8, 2019 |  BC Innovations  |  Targets & Mechanisms

Flipping the switch in immuno-oncology

Tumor myeloid cells are emerging as prime candidates for filling a hole in the immuno-oncology tool box, offering targets that can simultaneously release the brakes and rev up the gas in the immune system. As...