21:44 , Jul 10, 2018 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Other An encapsulated, ionic solvent-based formulation of insulin could enable longer-lasting treatment of Type I diabetes than injected insulin. The formulation consists oral, enterically coated capsules containing insulin dispersed in a deep eutectic solvent (cationic/anionic...
21:39 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Liver cancer In vitro, cell culture and mouse studies identified a SALL4-derived peptide inhibitor of the SALL4-RBBP4 interaction that could help treat hepatocellular carcinoma (HCC). Chemical synthesis and in vitro testing of analogs of a...
21:35 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes Mouse studies suggest inhibiting FST could help treat insulin resistance and glucose intolerance. In a genetic mouse model of glucose intolerance and hyper insulinemia, liver-specific knockdown of FST decreased hepatic glucose production, serum insulin...
03:04 , Jun 30, 2018 |  BioCentury  |  Finance

Eyes on launches

The annual summer slowdown isn’t restricted to just the stock market this year, as the clinical catalyst calendar also appears to be on holiday in 3Q18. Buysiders are therefore turning their attention to a spate of...
00:51 , Jun 23, 2018 |  BioCentury  |  Strategy

Gawande’s Cheesecake Factory

Details about the healthcare organization Atul Gawande will run for Amazon.com Inc., Berkshire Hathaway Inc. and J. P. Morgan Chase & Co. are scarce -- basic facts, starting with its name, have not been disclosed....
22:55 , Jun 22, 2018 |  BC Extra  |  Preclinical News

Blocking LSD1 could activate cancer immune response via HERV

A Harvard Medical School team led by immunology and pathology professor Arlene Sharpe has shown inhibiting lysine-specific demethylase (LSD1; KDM1A) increases human endogenous retrovirus (HERV) transcription to activate an immune response that could help treat...
18:35 , Jun 22, 2018 |  BC Week In Review  |  Financial News

Emulate raises $36M series C to improve Organ-Chips offering

Emulate Inc. (Boston, Mass.) raised on June 19 $36 million in a series C round led by Founders Fund. Fellow new investors ALS Investment Fund, SciFi VC and Glass Wall Syndicate also participated, as did...
18:09 , Jun 22, 2018 |  BC Week In Review  |  Company News

UC Regents get CRISPR guide RNA patent in U.S.

The U.S. Patent Office on June 19 granted a patent related to CRISPR-Cas9 gene editing technology to the Regents of the University of California, the University of Vienna and Emmanuelle Charpentier covering use of guide...
18:08 , Jun 22, 2018 |  BC Week In Review  |  Company News

Gawande to head Amazon-Berkshire-Chase healthcare company

Amazon.com Inc. (NASDAQ:AMZN), Berkshire Hathaway Inc. (NYSE:BRK.A; NYSE:BRK.B) and JPMorgan Chase & Co. (NYSE:JPM) hired Atul Gawande as CEO of their new company focused on U.S. employee healthcare, effective July 9. His experience draws from...
23:00 , Jun 20, 2018 |  BC Extra  |  Company News

Gawande to head Amazon-Berkshire-Chase healthcare company

Amazon.com Inc. (NASDAQ:AMZN), Berkshire Hathaway Inc. (NYSE:BRK.A; NYSE:BRK.B) and JPMorgan Chase & Co. (NYSE:JPM) hired Atul Gawande as CEO of their new company focused on U.S. employee healthcare, effective July 9. His experience draws from...