BioCentury | May 17, 2018
Translation in Brief

A LRRK-ing link

In a pair of studies, researchers from Icahn School of Medicine at Mount Sinai identified links between Parkinson’s disease and inflammatory bowel disease that could spur the development of existing therapies for new indications. In...
BioCentury | May 3, 2018
Translation in Brief

Hydrogels on demand

Alivio Therapeutics is using a hydrogel platform to develop controlled-release therapies for inflammatory diseases that respond to flare-ups as they occur. The approach, described in an April Nature Communications study, could avoid systemic toxicities associated...
BioCentury | Oct 5, 2017
Translation in Brief

Chronic neuroprotection

Two studies by Genentech have shown DLK inhibition is neuroprotective in two chronic neurodegenerative diseases and suggest the target may play a broad role in driving neurodegeneration, regardless of the underlying cause. MAP kinase kinase...
BioCentury | Jul 27, 2017
Product R&D

Spheres of influence

AstraZeneca plc and Genentech Inc. have joined forces to test whether a liver spheroid system can improve upon the gold standard for preclinical prediction of hepatotoxicity. The goal is to raise the bar on preventing...
BioCentury | Feb 16, 2017
Translation in Brief

A wrinkle in prion

A form of fatal encephalitis called variant Creutzfeldt-Jakob disease has been transmitted through blood transfusions at least four times in the U.K. because no test exists that can screen blood samples for the misfolded prion...
BioCentury | Nov 3, 2016
Translation in Brief

The I’s have it

A Science study has revealed that anti-inflammatory drugs targeting tumor necrosis factor α (TNFα) work in part by downregulating interleukin-22 receptor subunit alpha 2 (IL22RA2; IL-22BP) to increase IL-22 activity. The findings not only suggest...
BioCentury | Aug 4, 2016
Translation in Brief

Cutting losses in ALS

Studies investigating how C9orf72 mutations cause amyotrophic lateral sclerosis (ALS) have largely focused on toxic gain-of-function mechanisms driven by the abnormal transcripts, which contain repeat expansions of various sizes. But C9orf72 mutations also result in...
BioCentury | Jul 21, 2016
Tools & Techniques

A new route for CARs

By retooling chimeric antigen receptor (CAR) T cell technology to kill autoimmune cells rather than tumor cells, a University of Pennsylvania team is creating therapies for autoimmune diseases to be as effective as those for...
BioCentury | May 12, 2016
Targets & Mechanisms

Another shot at the flu

While most efforts to suppress flu focus on boosting the immune system through vaccination, a group at Yale University has found evidence showing it is the inflammatory response to infection, not the infection itself, that...
BioCentury | Dec 10, 2015
Product R&D

Spark in the brain

Spark Therapeutics Inc. is expanding beyond eye and blood diseases with its first foray into the brain for the rare neuronal disorder Batten disease, using a gene therapy delivered to the ependymal cells in the...
Items per page:
1 - 10 of 17
BioCentury | May 17, 2018
Translation in Brief

A LRRK-ing link

In a pair of studies, researchers from Icahn School of Medicine at Mount Sinai identified links between Parkinson’s disease and inflammatory bowel disease that could spur the development of existing therapies for new indications. In...
BioCentury | May 3, 2018
Translation in Brief

Hydrogels on demand

Alivio Therapeutics is using a hydrogel platform to develop controlled-release therapies for inflammatory diseases that respond to flare-ups as they occur. The approach, described in an April Nature Communications study, could avoid systemic toxicities associated...
BioCentury | Oct 5, 2017
Translation in Brief

Chronic neuroprotection

Two studies by Genentech have shown DLK inhibition is neuroprotective in two chronic neurodegenerative diseases and suggest the target may play a broad role in driving neurodegeneration, regardless of the underlying cause. MAP kinase kinase...
BioCentury | Jul 27, 2017
Product R&D

Spheres of influence

AstraZeneca plc and Genentech Inc. have joined forces to test whether a liver spheroid system can improve upon the gold standard for preclinical prediction of hepatotoxicity. The goal is to raise the bar on preventing...
BioCentury | Feb 16, 2017
Translation in Brief

A wrinkle in prion

A form of fatal encephalitis called variant Creutzfeldt-Jakob disease has been transmitted through blood transfusions at least four times in the U.K. because no test exists that can screen blood samples for the misfolded prion...
BioCentury | Nov 3, 2016
Translation in Brief

The I’s have it

A Science study has revealed that anti-inflammatory drugs targeting tumor necrosis factor α (TNFα) work in part by downregulating interleukin-22 receptor subunit alpha 2 (IL22RA2; IL-22BP) to increase IL-22 activity. The findings not only suggest...
BioCentury | Aug 4, 2016
Translation in Brief

Cutting losses in ALS

Studies investigating how C9orf72 mutations cause amyotrophic lateral sclerosis (ALS) have largely focused on toxic gain-of-function mechanisms driven by the abnormal transcripts, which contain repeat expansions of various sizes. But C9orf72 mutations also result in...
BioCentury | Jul 21, 2016
Tools & Techniques

A new route for CARs

By retooling chimeric antigen receptor (CAR) T cell technology to kill autoimmune cells rather than tumor cells, a University of Pennsylvania team is creating therapies for autoimmune diseases to be as effective as those for...
BioCentury | May 12, 2016
Targets & Mechanisms

Another shot at the flu

While most efforts to suppress flu focus on boosting the immune system through vaccination, a group at Yale University has found evidence showing it is the inflammatory response to infection, not the infection itself, that...
BioCentury | Dec 10, 2015
Product R&D

Spark in the brain

Spark Therapeutics Inc. is expanding beyond eye and blood diseases with its first foray into the brain for the rare neuronal disorder Batten disease, using a gene therapy delivered to the ependymal cells in the...
Items per page:
1 - 10 of 17