01:30 , Jul 13, 2019 |  BioCentury  |  Tools & Techniques

Broadening role for external control arms in clinical trials

External control arms are moving from theory to practice as drug developers begin to use them to make internal go/no-go decisions for clinical programs and to support regulatory applications. The field is largely split between...
20:04 , Apr 25, 2019 |  BC Innovations  |  Finance

The academic founders' conundrum

First-time academic entrepreneurs face a circular problem: while they’re continually sought after by VCs and pharmas seeking the next “big thing”, they also face an arduous path to establish their bona fides - not for...
23:04 , Dec 20, 2018 |  BC Innovations  |  Finance

Third Rock keeps its options open

Third Rock Ventures is cementing its strategy to create newcos that can succeed as stand-alone companies. The VC has ditched the build-to-buy model in favor of one that gives a pharma broad options to multiple...
00:00 , Sep 8, 2018 |  BioCentury  |  Product Development

Data distribution

TransCelerate BioPharma Inc. is taking its data sharing initiative to the next level with a new platform that will integrate clinical and preclinical data sets in a single repository and provide new analytical tools. DataCelerate,...
01:37 , Aug 10, 2018 |  BC Innovations  |  Finance

Super-sized ambitions

A trend toward super-sized initial financings is attracting a new set of deep-pocketed investors to the early stage space. These new players are making earlier commitments with hopes of guaranteeing larger ownership positions at an...
18:45 , Nov 27, 2017 |  BC Innovations  |  Distillery Therapeutics

Gastrointestinal; cancer

INDICATION: Colitis; colorectal cancer Mouse studies suggest iron chelation or superoxide reduction could help treat colitis or colitis-induced colorectal cancer. In a mouse model of acute colitis, the iron-chelating agent Ferriprox deferiprone increased body weight...
21:09 , Sep 15, 2017 |  BC Week In Review  |  Company News

Merck forms big data cancer alliance

Merck KGaA (Xetra:MRK) is collaborating with Project Data Sphere, a non-profit initiative of the CEO Roundtable on Cancer's Life Sciences Consortium, to form a big data platform of clinical and real-world oncology data and analytical...
16:33 , Mar 30, 2017 |  BC Extra  |  Financial News

Third Rock launches Tango with $55M

Third Rock Ventures launched Tango Therapeutics Inc. (Cambridge, Mass.) with a tranched $55 million series A round. The firm is the newco's sole investor. Details of the tranches are undisclosed. The biotech is using a...
22:27 , Mar 16, 2017 |  BC Innovations  |  Product R&D

Neo wave

The central thesis in the increasingly hot field of neoantigens is to pick mutations from patient tumors and turn them into personalized immunotherapies. While companies are staking out their space by defining how they will...
02:16 , Jan 21, 2017 |  BioCentury  |  Tools & Techniques

Hopes in the machine

Applying machine learning tools to drug R&D could usher in a new era of effective therapies targeting causative disease drivers, higher success rates in clinical trials and real-world tools to manage adherence, prevent adverse events...