18:50 , Nov 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Mouse studies suggest inhibiting BMP6 or promoting NOG expression could help treat cognitive dysfunction in AD. In a mouse model of AD, levels of BMP6 in the hippocampal dentate gyrus were...
22:07 , Sep 13, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...
17:21 , Aug 30, 2018 |  BC Innovations  |  Tools & Techniques

Master of autism

The discovery of a master regulator of autism risk genes has yielded the first mouse model of the form of the condition that accounts for about 90% of patients, and could spark a new way...
07:00 , May 16, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A); epidermal growth factor receptor (EGFR) Cell culture and mouse studies suggest inhibiting DYRK1A could...
07:00 , Jun 2, 2011 |  BC Innovations  |  Targets & Mechanisms

Getting at the crux of the antigen

Novartis AG researchers have used structure-based antigen design to rationally optimize vaccines for respiratory syncytial virus 1 and Group B Streptococcus . 2 Although the strategy itself is not new, the work serves as proof...
07:00 , Jul 22, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Immunosuppressive innate immune cells for heart transplant A study in mice suggests that transplantation of monocytes could help increase graft tolerance. In mice with low...
07:00 , Jul 22, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Assays & screens

Approach Summary Licensing status Publication and contact information Assays & screens Solution capture and high throughput DNA sequencing for the detection of cancer mutations Solution capture and high throughput sequencing of patient DNA samples could...