19:30 , Aug 8, 2019 |  BC Innovations  |  Distillery Techniques

Nanoparticle-based system for nucleic acid therapy delivery and monitoring of disease progression in thoracic aortic dissection

TECHNIQUES CATEGORY: Drug delivery; imaging TECHNOLOGY: Nanoparticles; MRI A nanoparticle-based system could deliver a nucleic acid therapy to thoracic aortic dissections to treat and non-invasively monitor earlier progression of the disease, which current methods cannot...
02:01 , Sep 29, 2018 |  BioCentury  |  Politics, Policy & Law

PROs in prime time

A recommendation by CMS’s MEDCAC catapults the collection of PRO data to the postmarket setting from their more familiar spot in clinical development. CAR T leaders Novartis AG and Gilead Sciences Inc., however, are not...
18:07 , May 15, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Patient sample and mouse experiments suggest that inhibiting CEBPB could help treat AD. In postmortem brain tissue samples from patients, levels of CEBPB were higher than in samples from unaffected subjects....
08:00 , Feb 11, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Destrin (actin depolymerizing factor) (DSTN)

Neurology INDICATION: Stroke Mouse studies suggest promoting DSTN expression could help treat stroke. In a mouse model of ischemic stroke, viral vector-mediated expression of a constitutively active form of DSTN in microvascular endothelial cells decreased...
08:00 , Dec 3, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Legumain (LGMN; AEP)

Neurology INDICATION: Alzheimer's disease (AD) In vitro, patient sample and mouse studies suggest inhibiting LGMN could help treat AD. Levels of LGMN were higher in postmortem brain tissue samples from AD patients than from healthy...
08:00 , Dec 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Stroke; sepsis Phosphoglycerate kinase 1 (PGK1); heat shock protein 90 (Hsp90) In vitro and rodent models suggest the generic hypertension drug terazosin could help treat...
08:00 , Dec 11, 2014 |  BC Innovations  |  Targets & Mechanisms

Terazosin reborn

In searching for compounds to treat stroke or sepsis, a Chinese team has found a new activity-and possibly a new indication-for an old drug. Terazosin, a generic a-blocker used in hypertension, inhibited apoptosis and extended...
07:00 , Jul 31, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker /pathway Summary Licensing status Publication and contact information Cardiovascular disease Erectile dysfunction (ED); hypertension Phosphodiesterase-5 (PDE-5) An SAR study identified a class of vasodilators that may be useful for...