00:38 , Aug 16, 2019 |  BC Innovations  |  Emerging Company Profile

Grace: seeking cures in pathological roots

Grace Science is targeting the root of a recently discovered genetic disorder for not just the ultra-rare condition but also for common diseases including cancer. Grace Science LLC’s origins stem from the diagnosis of co-founder...
23:28 , Aug 8, 2019 |  BC Innovations  |  Translation in Brief

A cool menthol switch for gene expression

ETH Zurich researchers have created a synthetic gene circuit activated by topical menthol to switch on gene expression and protein production in engineered cells. In a July Nature Medicine paper , the team used the...
22:31 , Aug 8, 2019 |  BC Innovations  |  Translation in Brief

Lab mice with ‘wild’ microbiomes better reflect clinical data

A lab mouse line carrying a wild mouse microbiome recapitulated unexpected clinical results, showing that the rodents, from NIH, could serve as a better model for preclinical testing than conventional lab mice. Multiple studies have...
21:40 , Aug 8, 2019 |  BC Innovations  |  Distillery Therapeutics

Engineered cells with a synthetic gene switch for diabetes

DISEASE CATEGORY: Endocrine/Metabolic INDICATION: Diabetes Engineered cells with a synthetic gene circuit could treat diabetes. The system comprises implanted HEK cells encoding a synthetic calcium-responsive promoter and the insulin gene. In Type I diabetic mice,...
20:20 , Aug 8, 2019 |  BC Innovations  |  Emerging Company Profile

Akrevia: Masking immunotherapies en route to tumors

Akrevia is harnessing proteases to mask biologics in the periphery and switch them on when they reach the tumor environment to deliver highly immunostimulatory antibodies, cytokines and other immunotherapies that are otherwise toxic to tissues....
17:16 , Aug 8, 2019 |  BC Innovations  |  Distillery Therapeutics

Glucose-responsive insulin delivery for diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes A UCLA and North Carolina State University team funded by JDRF and Sanofi developed a charge-switchable polymer complex that could help treat diabetes by automatically delivering insulin in response to...
03:18 , Aug 2, 2019 |  BC Innovations  |  Product Development

Boehringer plays catch-up in NASH, dives into new modalities across the board

Although Boehringer’s recent spate of deals plug pipeline holes in fibrosis and cancer, a broader survey of the pharma’s partnering activity over the last two years shows it delving into technologies that let it jump...
22:20 , Aug 1, 2019 |  BC Innovations  |  Translation in Brief

Making connections between ALS and gut microbes

Israeli researchers have linked gut microbiome species and metabolic pathways to ALS and shown that different species can ameliorate or exacerbate disease. The microbiome and gut-brain axis have increasingly been implicated in neurological disorders including...
04:39 , Aug 1, 2019 |  BC Innovations  |  Distillery Therapeutics

DEGS1 inhibition for insulin resistance and hepatic steatosis

DISEASE CATEGORY: Endocrine/metabolic; hepatic INDICATION: Diabetes; hepatic A University of Utah team led by Centaurus Therapeutics Inc. co-founder Scott Summers showed that DEGS1 inhibition could treat and prevent insulin resistance and hepatic steatosis. In mice...
04:38 , Aug 1, 2019 |  BC Innovations  |  Distillery Therapeutics

ARID5A as a therapy for obesity

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Obesity Raising activity levels of the transcription factor ARID5A could help treat obesity by inhibiting PPARγ-mediated adipogenesis. ARID5A overexpression decreased adipogenesis and repressed transcription of PPARγ, a master regulator of the...