21:18 , Jul 11, 2018 |  BC Extra  |  Preclinical News

Turning cancer cells against their own kind

To overcome hurdles facing cancer cell-based therapies such as self-toxicity and long-term persistence, researchers from Brigham and Women's Hospital and colleagues developed a two-part therapy by pairing tumor cells delivering a receptor-targeted anticancer agent with...
21:39 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Liver cancer In vitro, cell culture and mouse studies identified a SALL4-derived peptide inhibitor of the SALL4-RBBP4 interaction that could help treat hepatocellular carcinoma (HCC). Chemical synthesis and in vitro testing of analogs of a...
18:08 , Jun 22, 2018 |  BC Week In Review  |  Company News

Gawande to head Amazon-Berkshire-Chase healthcare company

Amazon.com Inc. (NASDAQ:AMZN), Berkshire Hathaway Inc. (NYSE:BRK.A; NYSE:BRK.B) and JPMorgan Chase & Co. (NYSE:JPM) hired Atul Gawande as CEO of their new company focused on U.S. employee healthcare, effective July 9. His experience draws from...
23:00 , Jun 20, 2018 |  BC Extra  |  Company News

Gawande to head Amazon-Berkshire-Chase healthcare company

Amazon.com Inc. (NASDAQ:AMZN), Berkshire Hathaway Inc. (NYSE:BRK.A; NYSE:BRK.B) and JPMorgan Chase & Co. (NYSE:JPM) hired Atul Gawande as CEO of their new company focused on U.S. employee healthcare, effective July 9. His experience draws from...
16:32 , Jun 6, 2018 |  BC Innovations  |  Translation in Brief

JAKs and clots

Brigham and Women’s Hospital researchers have uncovered the mechanisms behind a major complication in bone marrow disorders by linking a JAK-2 mutation with thrombosis in patients and mice, and identified a way to treat blood...
17:21 , May 11, 2018 |  BC Week In Review  |  Company News

Aetion partners with Brigham and FDA to replicate clinical trials with real-world evidence

Analytics software company Aetion Inc. (New York, N.Y.) partnered with FDA and Brigham and Women’s Hospital to recreate 30 published clinical trials using real-world evidence (RWE) in order to determine if the data can be...
19:14 , May 8, 2018 |  BC Extra  |  Company News

Aetion partnership to replicate clinical trials with real-world evidence

Analytics software company Aetion Inc. (New York, N.Y.) partnered with FDA and Brigham and Women’s Hospital to recreate 30 published clinical trials using real-world evidence (RWE) in order to determine if the data can be...
23:22 , May 7, 2018 |  BC Extra  |  Tools & Techniques

Study finds precision medicine speeds drug approval

A new study in a special precision medicine-focused issue of Health Affairs showed that drugs targeted at patients in pivotal trials based on genetic characteristics were approved by FDA an average of 1.7 years faster...
17:51 , May 3, 2018 |  BC Innovations  |  Translation in Brief

Hydrogels on demand

Alivio Therapeutics is using a hydrogel platform to develop controlled-release therapies for inflammatory diseases that respond to flare-ups as they occur. The approach, described in an April Nature Communications study, could avoid systemic toxicities associated...
16:02 , Apr 18, 2018 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Rheumatoid arthritis (RA) Patient sample and mouse studies suggest a hydrogel-based formulation of the GCCR agonist triamcinolone acetonide could help treat RA and other forms of inflammatory arthritis. The hydrogel contains injectable triglycerol monostearate that...