21:02 , Jun 6, 2019 |  BC Innovations  |  Emerging Company Profile

Scipher: decoding drug response from protein interactions

To improve the accuracy of therapeutic response predictions, Scipher has incorporated protein-protein interaction maps into its machine learning-based analyses of patient gene expression data to spotlight pathologically relevant markers. According to Scipher Medicine Corp. CEO...
12:00 , May 21, 2019 |  BC Extra  |  Financial News

Sequoia leads digital therapeutics company Biofourmis' $35M round

Biofourmis raised $35 million in a series B round to develop its AI-powered digital therapeutics platform for improving patient outcomes. The platform uses AI, drug intervention, wearable sensors and a smartphone app to remotely monitor...
14:00 , Apr 17, 2019 |  BC Innovations  |  Emerging Company Profile

Nocion: Targeting pain neurons and nothing else

With a $27 million series A co-led by Canaan and F-Prime Capital announced Wednesday, Nocion thinks it could replace opioids in a range of tissue-localized indications, starting with cough. The company is aiming to minimize...
18:45 , Apr 12, 2019 |  BC Week In Review  |  Company News

International partners to develop immune stimulants for neurology

Brigham and Women's Hospital, immunology company I-Mab Biopharma, neurology company Jiangsu NHWA and CDMO Biodextris partnered to develop intranasally delivered biologics that stimulate the immune system to treat neurological diseases. Weimin Tang, global business head...
19:43 , Apr 10, 2019 |  BC Extra  |  Clinical News

Aetion, Brigham and Women's partnerships will inform FDA RWE standards

FDA is expanding its real-world evidence partnership with Brigham and Women's Hospital and Aetion to use real-world evidence to predict clinical outcomes from trials. The results from this expansion should help the agency identify when...
13:55 , Apr 10, 2019 |  BC Innovations  |  Distillery Therapeutics

Inhibiting a MYLK splice variant for IBD and colitis

DISEASE CATEGORY: Autoimmune; gastrointestinal INDICATION: Inflammatory bowel disease (IBD); colitis Cell culture and mouse studies identified an inhibitor of an MYLK isoform that could help treat IBD and colitis. In silico screening of a compound...
19:09 , Feb 28, 2019 |  BC Innovations  |  Translation in Brief

Damming up metastasis

Wyss Institute researchers and colleagues have developed non-aggregating platelets that could prevent cancer metastasis. As described this month in Science Translational Medicine , the team reduced the binding capability of normal human platelets with a...
01:47 , Feb 15, 2019 |  BC Week In Review  |  Company News

IBM, Broad to use AI to improve CV genetic risk prediction

The Broad Institute of MIT and Harvard and the IBM Watson Health business of IBM Corp. (NYSE:IBM) have teamed up to develop artificial intelligence algorithms to improve the predictive power of polygenic scoring of cardiovascular...
21:15 , Feb 13, 2019 |  BC Extra  |  Company News

IBM, Broad to use AI to improve CV genetic risk prediction

The Broad Institute of MIT and Harvard and the IBM Watson Health business of IBM Corp. (NYSE:IBM) have teamed up to develop artificial intelligence algorithms to improve the predictive power of polygenic scoring of cardiovascular...
13:30 , Feb 13, 2019 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Other An ingestible device could enable oral delivery of biologics for injection into the stomach lining. The device is a self-orienting millimeter-scale applicator (SOMA) with a tortoise shape to promote adoption of the correct...