17:08 , Feb 6, 2018 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Mouse studies suggest inhibiting DLL4 could help treat diabetes. In a mouse model of diabetes, an anti-DLL4 antibody decreased hyperglycemia compared with a control antibody. In another mouse model of diabetes, the anti-DLL4...
22:08 , Apr 4, 2017 |  BC Innovations  |  Distillery Therapeutics

Inflammation

INDICATION: Asthma Patient sample, cell culture and mouse studies suggest stimulating T cells with activin A could help treat allergic asthma. In primary CD4 + T cells isolated from asthma patients and stimulated with mixed-grass...
08:00 , Feb 6, 2014 |  BC Innovations  |  Tools & Techniques

RNA is for activation

Although siRNA-based therapeutics have recently been clinically validated as a strategy to knock down gene expression, a lesser-known function for short double-stranded RNAs is their ability to turn on the expression of target genes. Now,...
07:00 , Aug 13, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Allergy; asthma Inhibin, bA (INHBA; activin A) Studies in mice suggest that activin A could be useful for treating allergen-induced asthma. In a mouse model...