21:35 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Melanoma, colorectal cancer In vitro , cell culture and mouse studies identified an aminopyrimidine-based dual MAPK1/MAPK3 inhibitor that could help treat BRAF-mutant melanoma and colorectal cancer. Fragment-based screening, chemical synthesis and in vitro enzyme...
22:18 , Jan 5, 2018 |  BC Week In Review  |  Clinical News

BioMed Valley's ulixertinib leads to partial responses in Phase I for solid tumors

BioMed Valley Discoveries Inc. (Kansas City, Mo.) said twice-daily oral ulixertinib (BVD-523) at doses of ≥600 mg led to 14 partial responses in about 101 evaluable patients with advanced solid tumors in a two-part Phase...
07:00 , Aug 20, 2015 |  BC Innovations  |  Finance

Gladstone adds for profit

The not-for-profit Gladstone Institutes is expanding its deal capacity by creating Cure Network Ventures Inc., a wholly owned for-profit company within its walls aimed at attracting funding organizations and industry partners. While Gladstone sees the...
07:00 , Sep 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Not applicable Rodent, canine and human studies suggest intratumoral injection of spores from the attenuated strain of Clostridium novyi (C. novyi-NT) could help treat...
07:00 , Jun 12, 2014 |  BC Innovations  |  Targets & Mechanisms

Putting SMYD3 on the MAP

Stanford University and GlaxoSmithKline plc researchers have uncovered the mechanism of action of SMYD3 , a histone lysine methyltransferase overexpressed in many lung and pancreatic tumors. 1 The surprise was that SMYD3 acts in the...
07:00 , Sep 15, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Protocol for promoting hematopoietic stem cell (HSC) self-renewal and expansion to improve transplant outcomes A method for increasing self-renewal and expansion of HSCs could help...