20:33 , Dec 6, 2018 |  BC Innovations  |  Translation in Brief

Opening chromatin: long-term detriment?

An Institute for Research in Biomedicine team has shown increasing chromatin accessibility in cancer could promote tumor aggressiveness, not reduce tumor mutation burden (TMB) as previously thought. The findings, reported last month in Nature Cell...
18:44 , May 30, 2018 |  BC Innovations  |  Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds Selective peptidomimetic PREP inhibitors that cross the BBB could be used to probe the protein’s role in Parkinson’s disease, schizophrenia and other neurological diseases. Chemical synthesis, in vitro testing in enzyme activity...
19:13 , Feb 21, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer; colorectal cancer Mouse studies suggest combining inhibitors of TGFβ signaling with anti-PD-L1 therapies could help treat breast and colorectal cancers. In a mouse model of breast cancer in which T cells cannot...
17:01 , Jan 31, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Tumor levels of RPS6KA5 could help predict survival in ESR1-positive breast cancer. In 193 patients, low primary tumor levels of RPS6KA5 mRNA were associated with poor metastasis-free survival. In another 214 patients,...