03:36 , Jan 4, 2019 |  BC Innovations  |  Tools & Techniques

Making AD mice as diverse as patients

The Jackson Laboratory aims to make Alzheimer’s disease mouse models more useful for predicting which patients will respond to therapy by engineering in a high degree of genetic diversity to better reflect trial populations. The...
00:07 , Sep 28, 2018 |  BC Innovations  |  Tools & Techniques

Deconstructing tox in immuno-oncology

The best route to improving preclinical toxicity in immunotherapies could lie in reverse translation, feeding clinical data back into the preclinical space to inform model development, rather than trying to guess a priori what the...
18:04 , Aug 29, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest inhibiting S100A4 or depleting S100A4-expressing cells could help treat glioblastoma multiforme (GBM) and other gliomas. In samples from glioma patients, high tumor levels of...
21:33 , Dec 16, 2016 |  BioCentury  |  Emerging Company Profile

Floral delivery

Instability and poor penetration can make topical delivery of proteins and peptides into the skin inefficient and inconsistent. Azitra Inc. is using an engineered human commensal strain of bacteria to consistently deliver therapeutic proteins to...
07:00 , Oct 31, 2016 |  BC Week In Review  |  Company News

Caribou Biosciences, The Jackson Laboratory deal

Caribou granted the non-profit Jackson Laboratory non-exclusive, worldwide rights to CRISPR- Cas9 technology and IP to create custom-built mouse models. The partners declined to disclose financial terms. Caribou Biosciences Inc. , Berkeley, Calif.  The Jackson...
07:00 , Aug 22, 2016 |  BC Week In Review  |  Company News

The Jackson Laboratory, NIH neurology news

The Jackson Laboratory received a five-year, $11.7 million grant from NIH’s National Institute on Drug Abuse (NIDA) to create the Center for Systems Neurogenetics of Addiction (CSNA). At the CSNA, university neuroscientists, computational biologists and...
23:45 , May 13, 2016 |  BC Extra  |  Top Story

White House launches National Microbiome Initiative

On Friday, the White House Office of Science and Technology Policy (OSTP) announced the National Microbiome Initiative (NMI), which will seek to enhance the understanding of microbiome behavior and promote healthy microbiome function. The initiative,...
08:00 , Dec 7, 2015 |  BC Week In Review  |  Company News

The Jackson Laboratory, Cyteir deal

The Jackson Lab granted Cyteir exclusive rights to IP covering compounds that target undisclosed DNA repair enzymes. Cyteir said it will develop the compounds for cancer and autoimmune diseases. Cyteir also said Jackson is eligible...
08:00 , Dec 3, 2015 |  BC Innovations  |  Product R&D

Microbiome at the checkpoint

The growing belief that the microbiome can be harnessed to treat cancer has arguably received its biggest boost to date with the publication of two papers in Science linking two of the hottest targets in...
08:00 , Nov 19, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: A knock-in, knockout, transgenic mouse model of moderate spinal muscular atrophy (SMA)

Disease models TECHNOLOGY: Transgenics and knockouts A mouse model of moderate SMA could be useful for testing therapies administered long after disease onset. The mouse model was generated via knockout of one mouse survival of...